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BAX — PIK3CA
Text-mined interactions from Literome
Parikh et al., J Immunol 2004
:
Because inhibition of
PI3K or its target Akt also
triggers mitochondrial translocation of
Bax in T cells and apoptosis in Bax transfected cell lines, we generated Bax deletion mutants to identify the region ( s ) that confers sensitivity to regulation by MEK1 and Akt
Iwase et al., Int J Oncol 2007
(Carcinoma, Squamous Cell...) :
Expression of Bcl-2, cellular inhibitor of apoptosis protein-1 ( cIAP-1 ), and X-linked IAP was down-regulated, and expression of
Bax was
up-regulated by
PI 3-K inhibitors, while that of Bcl-xL, Bak and cIAP-2 was not attenuated
Kim et al., Mol Cancer Res 2008
(MAP Kinase Signaling System...) :
Inhibition of
PI3K also
suppressed SEK-1/MKK-4 and JNK activation,
Bax and Bak activation, and Bcl-2 down-regulation
Kolliputi et al., Am J Physiol Lung Cell Mol Physiol 2009
(Acute Lung Injury...) :
IL-6 cytoprotection in hyperoxic acute lung injury occurs via
PI3K/Akt mediated
Bax phosphorylation ... Thus IL-6 functions in a cytoprotective manner, in part, by suppressing Bax translocation and dimerization through
PI3K/Akt mediated
Bax phosphorylation
Zhang et al., Int J Radiat Oncol Biol Phys 2012
(Lung Injury...) :
Apoptosis correlated with increased PTEN expression,
inhibition of downstream
PI3K/AKT signaling, and increased p53 and
Bax protein levels
Wang et al., Toxicol Lett 2013
(Cardiovascular Diseases) :
In addition, the
PI3K inhibitor partially
blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of
Bax protein expression