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ATP5O — REN
Text-mined interactions from Literome
Schweda et al., American journal of physiology. Renal physiology 2000
:
For this purpose we characterized the
effects of the endoplasmatic Ca ( 2+ )
-ATPase inhibitors thapsigargin ( 300 nM ) and cyclopiazonic acid ( 20 microM ) on
renin secretion from isolated perfused rat kidneys
Churchill et al., Life Sci 1990
:
There is evidence that three inhibitors of Na,
K-ATPase activity -- ouabain, K-free extracellular fluid, and vanadate --
inhibit renin secretion by increasing Ca2+ concentration in juxtaglomerular cells, but in the case of vanadate, it is uncertain whether the increase in Ca2+ is due to a decrease in Ca2+ efflux ( inhibition of Ca-ATPase activity, or inhibition of Na, K-ATPase activity, followed by an increase in intracellular Na+ and a decrease in Na-Ca exchange ) or to an increase in Ca2+ influx through potential operated Ca channels ( inhibition of electrogenic Na, K transport, followed by membrane depolarization and activation of Ca channels )
Cohen et al., Circ Res 1982
:
The addition of ouabain to the perfusate containing 11 g per 100 ml inhibited the release of renin, suggesting that inhibition of
Na-K-ATPase or the related changes in cellular volume or composition
prevented renin release