◀ Back to TNFRSF10D
TNFRSF10D — TNFSF10
Pathways - manually collected, often from reviews:
-
KEGG Apoptosis:
TNFSF10
→
TNFRSF10A/TNFRSF10B/TNFRSF10C/TNFRSF10D
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
TNFSF10
→
TNFRSF10A/TNFRSF10B/TNFRSF10C/TNFRSF10D
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
TNFSF10
→
TNFRSF10A/TNFRSF10B/TNFRSF10C/TNFRSF10D
(protein-protein, activation)
-
KEGG Measles:
TNFSF10
→
TNFRSF10A/TNFRSF10B/TNFRSF10C/TNFRSF10D
(protein-protein, activation)
-
KEGG Influenza A:
TNFSF10
→
TNFRSF10A/TNFRSF10B/TNFRSF10C/TNFRSF10D
(protein-protein, binding/association)
-
KEGG Cytokine-cytokine receptor interaction:
TNFSF10
→
TNFRSF10D
(protein-protein, activation)
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
→
TRAILR4 (trimer) complex (TNFRSF10D)
(modification, activates)
Clancy et al., Proc Natl Acad Sci U S A 2005, Mérino et al., Mol Cell Biol 2006, Pan et al., Science 1997, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR4 complex (TNFRSF10D-TNFSF10)
→
TRAILR4 (trimer) complex (TNFRSF10D)
(modification, collaborate)
Degli-Esposti et al., Immunity 1997*
Evidence: physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
TRAIL/TRAILR4 complex (TNFRSF10D-TNFSF10)
→
TRAIL (trimer) complex (TNFSF10)
(modification, collaborate)
Degli-Esposti et al., Immunity 1997*
Evidence: physical interaction
-
NCI Pathway Database TRAIL signaling pathway:
TRAILR4 (trimer) complex (TNFRSF10D)
→
TRAIL (trimer) complex (TNFSF10)
(modification, collaborate)
Degli-Esposti et al., Immunity 1997*
Evidence: physical interaction
-
WikiPathways Apoptosis Modulation and Signaling:
TNFRSF10D
→
TNFSF10
(inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TNFRSF10D
—
TNFSF10
(direct interaction, pull down)
Degli-Esposti et al., Immunity 1997*
-
IRef Dip Interaction:
TNFRSF10D
—
TNFSF10
(direct interaction, surface plasmon resonance)
Marsters et al., Curr Biol 1997*
-
IRef Hprd Interaction:
TNFRSF10D
—
TNFSF10
(in vivo)
Degli-Esposti et al., Immunity 1997*
-
IRef Hprd Interaction:
TNFRSF10D
—
TNFSF10
(in vitro)
Degli-Esposti et al., Immunity 1997*
-
IRef Intact Interaction:
TNFRSF10D
—
TNFSF10
(direct interaction, surface plasmon resonance)
Pavet et al., Cancer Res 2010
-
IRef Ophid Interaction:
TNFRSF10D
—
TNFSF10
(aggregation, confirmational text mining)
Degli-Esposti et al., Immunity 1997*
-
IRef Ophid Interaction:
TNFRSF10D
—
TNFSF10
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Rosato et al., Leukemia 2004
(Leukemia...) :
TRAIL/FP induced no discernible changes in FLIP, DR4, DR5, Mcl-1, or survivin expression, modest declines in levels of
DcR2 and c-IAP, but resulted in the marked transcriptional downregulation of XIAP
Hasel et al., Verh Dtsch Ges Pathol 2006
(Chronic Disease...) :
In CM,
TGFbeta/IFNgamma/TRAIL induced
TRAIL-R4 surface expression