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CASP10 — MCL1

Text-mined interactions from Literome

Yu et al., Cancer Res 2002 (MAP Kinase Signaling System) : Synergistic potentiation of STI571 mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase dependent down-regulation of Bcr-Abl and Bcl-2 ; caspase independent down-regulation of Bcl-x ( L ) and Mcl-1 ; activation of JNK, p38 MAPK, and p34 ( cdc2 ) ; and diminished phosphorylation of Stat5 and CREB
Rosato et al., Mol Cancer Ther 2002 (Leukemia) : Treatment of cells with FP/SB also resulted in the caspase mediated cleavage of Bcl-2 and caspase independent down-regulation of Mcl-1
Iglesias-Serret et al., Arch Biochem Biophys 2003 : Staurosporine also reduced Mcl-1 mRNA levels and this reduction was mostly caspase dependent
Snowden et al., Leukemia 2003 (Leukemia, Lymphocytic, Chronic, B-Cell) : CLL cells undergoing apoptosis showed a rapid caspase mediated cleavage of Mcl-1 , an antiapoptotic member of the Bcl-2 family implicated in CLL survival and poor prognosis
Hung et al., Anticancer Res 2003 (Uterine Cervical Neoplasms) : In addition, we demonstrated that down-regulation of Mcl-1 gene expression and activation of caspase-8 are associated with CAPE triggered cell apoptosis
Derouet et al., J Biol Chem 2004 : Neither the calpain inhibitor, carbobenzoxy-valinyl-phenylalaninal, nor the pan caspase inhibitor, benzyloxycarbonyl-VAD-fluoromethylketone, had any effect on Mcl-1 stability under these conditions
Herrant et al., Oncogene 2004 : Finally, Mcl-1 wt unlike Mcl-1 Delta127 inhibited Bim-EL induced caspase activation
Huang et al., Eur J Pharmacol 2004 (Prostatic Neoplasms) : Taken together, it is suggested that caseamembrin C-induced apoptosis is predominantly through the activation of intrinsic apoptosis pathways by causing the down-regulation of Bcl-2 and Bcl-xL expression, up-regulation of Mcl-1S protein and activation of caspase-9 and caspase-3
Rahmani et al., J Biol Chem 2005 (Leukemia) : Finally, ectopic expression of Mcl-1 in leukemic cells markedly inhibited BAY 43-9006 mediated cytochrome c cytosolic release, caspase-9 , -7, and -3 activation, as well as cell death, indicating that Mcl-1 operates upstream of cytochrome c release and caspase activation
Rosato et al., Mol Cancer Ther 2005 (Leukemia) : LAQ824/roscovitine treated cells displayed caspase dependent down-regulation of p21 ( CIP1 ) and Mcl-1 and a pronounced caspase independent reduction in X-linked inhibitor of apoptosis (XIAP) expression
Han et al., J Biol Chem 2006 : Loss of Mcl-1 contributes to an increased level of caspase activity downstream of the mitochondrial response to TRAIL
Liu et al., Ann Hematol 2007 (Leukemia) : Taken together, our results demonstrate for the first time that downregulation of cyclooxygenase-2 expression, disruption of mitochondrial membrane potential, activation of caspase-3 , downregulation of Bcl-2, Bcl-Xl, and Mcl-1 , and upregulation of Bax are involved in PPAR-gamma agonists induced apoptosis in these two human monocyte leukemia cells
Soga et al., Clin Exp Allergy 2007 (Dermatitis, Atopic) : Histamine also up-regulated the expression of Bcl-2 and Mcl-1 , and inhibited the activation of caspase-3
Soga et al., J Invest Dermatol 2007 (Dermatitis, Atopic) : 5-HT upregulated Bcl-2 and Mcl-1 , and inhibited the activation of caspase-3
Pan et al., Leukemia 2007 (Hypereosinophilic Syndrome) : The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha expressing cells through caspase-3 mediated cleavage of Mcl-1
Lin et al., J Biol Chem 2007 : Finally, we demonstrate that TRB2 induced cleavage and degradation of Mcl-1 are mediated via a caspase dependent but proteasome independent mechanism, and overexpression of Mcl-1 or its upstream activator Akt can markedly overcome the apoptogenic effect of TRB2
Soleymanlou et al., Am J Pathol 2007 (Anoxia...) : Preeclamptic placentae were characterized by caspase dependent cleavage of death suppressing Mcl-1L and switch toward cell death inducing Mcl-1S
Dasmahapatra et al., Clin Cancer Res 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Combined but not individual treatment of CML cells with vorinostat and sorafenib triggered pronounced mitochondrial dysfunction ( i.e., cytochrome c, Smac, and AIF release ), caspase activation , poly ( ADP-ribose ) polymerase cleavage, and down-regulation of Mcl-1
Podar et al., Oncogene 2008 (Multiple Myeloma) : We demonstrate that Bortezomib, but not doxorubicin, triggers caspase dependent generation of a 28 kDa Mcl-1-fragment , in several MM cell lines, including MM.1S cells
Chen et al., J Biol Chem 2007 : We observed that caspase-9 dimerization resulted in the loss of mitochondrial membrane potential and the cleavage of anti-apoptotic Bcl-2, Bcl-xL, and Mcl-1
Ke et al., Photochem Photobiol 2008 : The antiapoptotic protein Mcl-1 was extensively cleaved in a dose- and caspase dependent manner in Jurkat, but not in A431, cells exposed to Pc 4-PDT
Prince et al., J Immunol 2008 : Lysosomal disruption was followed by mitochondrial membrane permeabilization, caspase activation , and destabilization of Mcl-1
Hsiao et al., Naunyn Schmiedebergs Arch Pharmacol 2008 (Prostatic Neoplasms) : Next, it caused Bcl-2 phosphorylation on Ser-70, downregulation of Mcl-1 expression, and activation of caspase-3 , leading to apoptotic cell death
Callus et al., J Mol Biol 2008 : In BaF ( 3 ) cells, expression of Puma caused rapid caspase mediated cleavage of ICAD ( inhibitor of caspase activated deoxyribonuclease ) and Mcl-1 ( myeloid cell leukemia 1 ), leading to complete loss of cell viability
Feng et al., Int J Cancer 2009 (Carcinoma, Squamous Cell...) : Depletion of PLK1 activated the intrinsic apoptotic pathway, which was substantiated by loss of mitochondrial membrane potential, reduction of Mcl-1 and Bcl-2 as well as activation of caspase-9
Zhou et al., Neurol Res 2009 (Encephalitis...) : The following are the results of this work : ( 1 ) olomoucine reduced HSV-1 induced proliferation associated cyclin D1 expression ; ( 2 ) olomoucine also induced microglial cells apoptosis early at 24 hours post-infection and inhibited the release of proinflammatory cytokine and chemokine, including tumor necrosis factor alpha and monocyte chemoattractant protein 1 ; and ( 3 ) olomoucine induced apoptosis was caspase dependent , and it also reduced the antiapoptotic protein Mcl-1
Ahmed et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid...) : Inhibition of Mcl-1 by EGCG triggered caspase 3 activity in RA synovial fibroblasts, which was mediated via down-regulation of the TNFalpha induced Akt and NF-kappaB pathways
Chen et al., Cancer Lett 2010 (Leukemia, Erythroblastic, Acute...) : Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3 mediated cleavage of Mcl-1
Park et al., Toxicol In Vitro 2010 (Carcinoma, Squamous Cell...) : These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB
Fellenberg et al., PloS one 2010 (Osteosarcoma) : The observed chemoresistance was mediated at least in part by increased expression of the anti-apoptotic proteins Bcl-2, Mcl-1 , and XIAP, reduced activation of caspase-9 , and, consequently, reduced cleavage of the caspase substrate PARP
Drury et al., PloS one 2010 (Colorectal Neoplasms) : CXCL12 producing carcinomas cultured on poly-HEMA displayed heightened Bim and loss of Mcl-1 and Bcl-2 preceding cytochrome c release, and caspase-9 activation
Choi et al., Chem Biol Interact 2011 (Carcinoma, Renal Cell...) : Cafestol induced apoptosis is associated with the reduction of mitochondrial membrane potential ( MMP ), activation of caspase 3, cytochrome c release, and down-regulation of anti-apoptotic proteins ( Bcl-2, Bcl-xL, Mcl-1 and cFLIP )
Hu et al., Molecular cancer 2011 : Furthermore, inhibition of caspase-3 not only abrogated HBx triggered apoptotic killing but also blocked HBx induced Mcl-1 loss
Liao et al., Blood 2011 (Chronic Disease...) : In vitro treatment of human and rat NK leukemia cells with FTY720 led to caspase dependent apoptosis and decreased Mcl-1 expression in a time- and-dose dependent manner
Fecteau et al., Mol Med 2012 (Leukemia, Lymphocytic, Chronic, B-Cell) : One single dose of 10 µmol/L or the repeated addition of 1 µmol/L sorafenib caused caspase dependent apoptosis and reduced levels of phosphorylated B-RAF, C-RAF, extracellular signal regulated kinase ( ERK ), signal transducer and activator of transcription 3 ( STAT3 ) and myeloid cell leukemia sequence 1 (Mcl-1) in CLL cells in the presence of the microenvironment
Chan et al., J Virol 2012 : Temporal transcriptome and functional analyses identified heat shock protein 27 (HSP27) and Mcl-1 , two known regulators of caspase 3 activation, as being upregulated prior to the 48-h viability gate following HCMV infection
Song et al., Exp Cell Res 2013 : Silencing Mcl-1 sensitizes tumor cells to PDT induced apoptosis, and ectopic expression of Mcl-1 significantly delays Bax translocation to mitochondria and inhibits caspase-3 activity following PDT