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CDKN1A — IKBKB
Text-mined interactions from Literome
Ping et al., Int J Oncol 2006
(Breast Neoplasms) :
Mechanistic investigation demonstrated that
IKKbeta increased
p21 expression through upregulation of p21 mRNA level ... This novel finding indicated that
IKKbeta could
mediate cytoplasmic
p21 accumulation via activation of its downstream target Akt, which was known to phosphorylate p21 and lead to cytoplasmic localization of p21
Yang et al., J Cell Mol Med 2010
(Neoplasm Metastasis...) :
Loss of
IKKbeta activity
increases p53 stability and
p21 expression leading to cell cycle arrest and apoptosis ...
IKKbeta inhibitors can
increase the protein stability, nuclear accumulation and promoter binding activity of p53, leading to the
p21 gene transcription