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AHSA1 — HSP90AA1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(direct interaction, pull down)
Panaretou et al., Mol Cell 2002*
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(direct interaction, two hybrid)
Panaretou et al., Mol Cell 2002*
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(physical association, affinity chromatography technology)
Mollapour et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(physical association, affinity chromatography technology)
Tsutsumi et al., Proc Natl Acad Sci U S A 2012*
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(physical association, affinity chromatography technology)
Gano et al., Mol Cell Proteomics 2010
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(direct interaction, pull down)
Zurawska et al., Biochim Biophys Acta 2010*
-
IRef Biogrid Interaction:
AHSA1
—
HSP90AA1
(physical association, affinity chromatography technology)
Panaretou et al., Mol Cell 2002*
-
IRef Hprd Interaction:
AHSA1
—
HSP90AA1
(two hybrid)
Panaretou et al., Mol Cell 2002*, Lotz et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
AHSA1
—
HSP90AA1
(in vivo)
Panaretou et al., Mol Cell 2002*, Lotz et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
AHSA1
—
HSP90AA1
(in vitro)
Panaretou et al., Mol Cell 2002*, Lotz et al., J Biol Chem 2003*
-
IRef Intact Interaction:
Complex of 20 proteins
(association, tandem affinity purification)
Gano et al., Mol Cell Proteomics 2010
-
IRef Intact Interaction:
AHSA1
—
HSP90AA1
(physical association, two hybrid)
Lotz et al., J Biol Chem 2003*
-
IRef Intact Interaction:
Complex of 13 proteins
(association, pull down)
Orthwein et al., EMBO J 2012
-
IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Gano et al., Mol Cell Proteomics 2010
-
IRef Intact Interaction:
Complex of 46 proteins
(association, tandem affinity purification)
Gano et al., Mol Cell Proteomics 2010
-
IRef Ophid Interaction:
AHSA1
—
HSP90AA1
(aggregation, confirmational text mining)
Lotz et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
AHSA1
—
HSP90AA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Lotz et al., J Biol Chem 2003
:
In experiments with purified proteins,
Aha1 but not Hch1
stimulated the intrinsic ATPase activity of
Hsp90 5-fold ... In vivo experiments demonstrated that
Aha1 and Hch1
contributed to efficient activation of the heterologous
Hsp90 client protein v-Src
Meares et al., FEBS Lett 2004
:
Furthermore, with IGF-1 stimulation
Hsp90 inhibition
increased p38 activation, produced additive activation of p90RSK, and slightly increased the duration of ERK1/2 activation
Siligardi et al., J Biol Chem 2004
:
These data indicated that Sba1 and
Aha1 regulate
Hsp90 by influencing the conformational state of the `` ATP lid '' and consequent N-terminal dimerization, whereas Sti1 does not
Holmes et al., Cancer Res 2008
(Neoplasms) :
As
AHA1 increases the ATPase activity of
HSP90 , we hypothesized that modulation of AHA1 expression could influence the activity of client proteins and/or the cellular response to 17-AAG
Koulov et al., Mol Biol Cell 2010
(Cystic Fibrosis) :
Biological and structural basis for
Aha1 regulation of
Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis ... To elucidate the structural basis for ATPase
stimulation of human
Hsp90 by human
Aha1 , we have developed novel mass spectrometry approaches that demonstrate that the N- and C-terminal domains of Aha1 cooperatively bind across the dimer interface of Hsp90 to modulate the ATP hydrolysis cycle and client activity in vivo
Desjardins et al., Arterioscler Thromb Vasc Biol 2012
:
Finally, we show that overexpression of
AHA1 in ECs
promotes association of eNOS and
Hsp90 , phosphorylation of Ser-1179 of eNOS, increases NO production, and cell migration