Takizawa et al., Eur J Biochem 2002
:
A dominant negative mutant of PKR ( PKR-KR ) inhibited both the apoptosis and p38 activation induced by ASK1 in vivo
Yamawaki et al., J Clin Invest 2005
(Inflammation) :
In cultured ECs, reduction of TXNIP expression by small interfering RNA increased TRX binding to ASK1 and inhibited TNF activation of JNK/p38 and VCAM1 expression
Zhuang et al., Cell Signal 2006
(MAP Kinase Signaling System) :
Stimulation of UV and PGN activates D-p38 through D-MEKK1, heat shock induced activation of D-p38 signals through both D-MEKK1 and D-ASK1 Ouyang et al., J Neurochem 2006
(MAP Kinase Signaling System...) :
It was found that the activation of p38 and JNK was suppressed to almost the same extent as that of ASK1 in the ASK1-knock-down cells, suggesting that activated ASK1 is almost totally responsible for activation of p38/JNK Gu et al., Oncogene 2009
:
PIM1 phosphorylation of ASK1 on Ser83 inhibited ASK1 mediated c-Jun N-terminal kinase phosphorylation as well as p38 kinase phosphorylation