Goriely et al., Blood 2006
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Finally, experiments on DCs from IRF-3-deficient mice established that TLR4 induced IL-12p35 mRNA and IL-12p70 synthesis are impaired in absence of IRF-3 Aksoy et al., Blood 2007
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Because IRF-3 activity is also required for IL-12p70 synthesis, our findings provide a molecular basis for the decreased ability of LPS stimulated neonatal moDCs to elicit Th1-type responses