◀ Back to IL2
CD3E — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Chirmule et al., J Immunol 1999
:
Triggering of CD4 coreceptors on both human and murine T cells can suppress
TCR/CD3 induced secretion of
IL-2
Roger et al., J Immunol 2001
:
Cutting edge : Ly49A inhibits
TCR/CD3 induced apoptosis and
IL-2 secretion ... Ligation of Ly49A, but not Ly49A/H, with its ligand H-2D ( d ) or anti-Ly49A mAbs caused a specific inhibition of
TCR/CD3 induced
IL-2 secretion
Baier et al., Immunol Rev 2003
:
Nevertheless, the first concepts about PKC isotype heterogeneity of cellular localization and function emerged only recently, when the PKC-theta pathways were mapped to critical signaling networks that control
T cell receptor (TCR)/CD3 dependent
interleukin (IL)-2 production and proliferation in T lymphocytes
Takashi et al., Eur J Immunol 1991
:
IL2 alone
induced neither proliferation nor cell surface
TcR/CD3 expression
Mustelin et al., Science 1990
:
At doses that inhibited TPK activity and tyrosine phosphorylation of the TCR zeta subunit, but not phospholipase C activity, genistein prevented
TCR-CD3 mediated phospholipase C activation,
interleukin-2 receptor expression, and T cell proliferation ... At doses that inhibited TPK activity and tyrosine phosphorylation of the TCR zeta subunit, but not phospholipase C activity, genistein prevented
TCR-CD3 mediated phospholipase C activation,
interleukin-2 receptor expression, and T cell proliferation
Paolini et al., J Exp Med 1995
:
Furthermore, the mutations prevent Fc epsilon RI- but not
TCR/CD3 mediated
IL-2 release
Clements et al., Int Immunol 1993
(Lymphoproliferative Disorders) :
This subset of T cells does not proliferate or produce
IL-2 in
response to mitogenic signals or
TCR-CD3 ligation
Hoshi et al., Int Immunol 1994
:
The stimulation through
TCR-CD3 complexes by immobilized anti-CD3 antibody
induced the production of
IL-2 and activation induced cell death (ACD) in the majority of T cell hybridomas
Raab et al., Immunity 1997
:
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to
TCR zeta/CD3 induction of
interleukin-2
Soares et al., J Immunol 1998
:
V7 ( CD101 ) ligation inhibits
TCR/CD3 induced
IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation