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ERBB2 — NOTCH1

Text-mined interactions from Literome

Osipo et al., Oncogene 2008 (Breast Neoplasms) : ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor ... Trastuzumab or a dual epidermal growth factor receptor (EGFR)/ErbB-2 tyrosine kinase inhibitor ( TKI ) increased Notch activity by 2- to 6-fold in SKBr3, BT474 and MCF-7/HER2-18 cells
Lindsay et al., Clinical and translational science 2008 (Breast Neoplasms) : ErbB2 induces Notch1 activity and function in breast cancer cells ... ErbB2 induction of DNA synthesis, contact independent growth, and mammosphere induction required Notch1 ... Thus, cyclin D1 functions downstream as a genetic target of Notch1, amplifies Notch1 activity by repressing Numb, and identifies a novel pathway by which ErbB2 induces Notch1 activity via the induction of cyclin D1
Chen et al., J Biol Chem 1997 : Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH