Bigg et al., Eur J Biochem 2000
:
A MEK1 inhibitor ( PD98059 ) inhibited both basal and induced levels of TIMP-1 Kwak et al., Mol Cancer Res 2006
(Fibrosarcoma...) :
Among these kinases, the inhibition of only ERK1/2 pathway by PD98059, a specific inhibitor of MAPK/ERK kinase(MEK)-1, and transfection of dominant negative MEK 1 effectively blocked the TIMP-1 induction by TGF-beta1