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Iliopoulos et al., Cancer Res 2009
(Adrenal Cortex Diseases...) :
Using a PPNAD cell line, we showed that miR-449 was up-regulated and identified its direct target, WNT1-inducible signaling pathway protein 2 ( WISP2 ) ; in addition, pharmacologic inhibition of
PKA resulted in the up-regulation of
miR-449 leading to the suppression of WISP2
Lv et al., Leukemia 2012
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
High levels of
miR-142-3p resulted in low levels of cAMP and weak activity of
PKA , thus relieving the inhibitory effect of PKA on T-leukemic cell proliferation
Ghorpade et al., Mol Cell Biol 2012
:
Genetic and signaling perturbations presented the evidence that
miR-155 regulates
PKA signaling by directly targeting a negative regulator of PKA, protein kinase inhibitor alpha ( PKI-a )