◀ Back to IRS1
GSK3B — IRS1
Pathways - manually collected, often from reviews:
-
WikiPathways Insulin Signaling:
Complex of IRS1-PIK3CA
→
GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2
(activation)
Text-mined interactions from Literome
Pearce et al., Metabolism 2004
(Body Weight...) :
At 29 weeks of age,
GSK-3beta protein levels were 5-fold higher, and glycogen synthase activation ( -27 % ), glycogen levels ( -58 % ) and
insulin receptor substrate-1 (IRS-1) protein levels ( -67 % ) were significantly
reduced in skeletal muscle
Boissan et al., Am J Pathol 2005
(Carcinoma, Hepatocellular...) :
IRS-2 overexpression associated with IGF-2 and
IRS-1 overexpression and with
GSK-3beta inhibition
MacAulay et al., Cell Metab 2007
:
Insulin stimulated protein kinase B ( PKB/Akt ) and
GSK-3beta phosphorylation was higher in GSK-3alpha KO livers compared to wild-type littermates, and
IRS-1 expression was markedly
increased
Shimwell et al., Oncogene 2009
(Cell Transformation, Viral) :
However, Ad5E1A associates with
IRS-1 ,
increasing Akt and
GSK-3beta phosphorylation and tyrosine phosphorylation of IRS-1 itself
Nemoto et al., J Pharmacol Sci 2009
:
In cultured bovine adrenal chromaffin cells, 1 ) constitutive and negatively regulated activities of
GSK-3beta up- and down-regulated insulin receptor, insulin receptor substrate-1 (IRS-1), IRS-2, and Akt levels via controlling proteasomal degradation and protein synthesis ; 2 ) nicotinic receptor/protein kinase C-alpha (PKC-alpha)/extracellular signal regulated kinase ( ERK ) pathway
up-regulated IRS-1 and IRS-2 levels, enhancing insulin induced the phosphoinositide 3-kinase (PI3K)/Akt/GSK-3beta pathway ; 3 ) inhibition of calcineurin by cyclosporin A or FK506 down-regulated IRS-2 level, attenuating insulin-like growth factor-I (IGF-I) induced ERK and GSK-3beta pathways ; and 4 ) insulin, IGF-I or therapeutics ( e.g., lithium ) up-regulated the voltage dependent Na(v)1.7 sodium channel
Leng et al., J Endocrinol 2010
(Insulin Resistance) :
Furthermore, overexpression of constitutively active
GSK3 beta was
sufficient to induce
IRS1 degradation