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CDH1 — TGFB1

Text-mined interactions from Literome

Chimal-Monroy et al., Int J Dev Biol 1999 : Expression of N-cadherin , N-CAM, fibronectin and tenascin is stimulated by TGF-beta1 , beta2, beta3 and beta5 during the formation of precartilage condensations ... Results showed that TGF-beta1 , TGF-beta2, TGF-beta3, and TGF-beta5 differentially enhanced the expression of N-cadherin , N-CAM, fibronectin and tenascin in precartilage condensations, suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations
Janji et al., Int J Cancer 1999 (Melanoma) : Our data further illustrate the TGF-beta1 dependent up-regulation of integrin linked kinase and the nuclear translocation of beta-catenin, 2 intracellular proteins involved in integrin and cadherin signaling
Riedl et al., J Immunol 2000 : Functional involvement of E-cadherin in TGF-beta 1-induced cell cluster formation of in vitro developing human Langerhans-type dendritic cells
Wang et al., J Cell Physiol 2001 (Colonic Neoplasms) : Requirement of protein kinase Calpha, extracellular matrix remodeling, and cell-matrix interaction for transforming growth factorbeta regulated expression of E-cadherin and catenins
Xu et al., Cell Res 2003 (Carcinoma, Hepatocellular...) : Furthermore, TGF-beta1 induced the down-regulation of E-cadherin and the nuclear translocation of beta-catenin
Mollah et al., J Invest Dermatol 2003 : Namely, both expressed CDla, F-cadherin , and Langerin in the presence of TGF-beta1 and stimulated allogeneic T cells at a similar magnitude
Phanish et al., Biochem J 2006 : TGFbeta1 induced increases in CTGF and decreases in E-cadherin expression were Smad3 dependent, whereas increases in MMP-2 expression were Smad2 dependent
Wu et al., Kidney Int 2006 (Fibrosis...) : By double immunostaining and Western analysis, rapamycin blocked the TGF-beta1 induced loss of E-cadherin expression and de novo increase of the expression of alpha-SMA in a dose dependent manner
Tan et al., J Am Soc Nephrol 2006 (Body Weight...) : In vitro, paricalcitol abolished TGF-beta1 mediated E-cadherin suppression and alpha-smooth muscle actin and fibronectin induction in tubular epithelial cells, underscoring its ability to block directly the epithelial to mesenchymal transition ( EMT )
Yoshikawa et al., J Am Soc Nephrol 2007 : However, co-treatment with TSA completely prevented TGF-beta1 induced morphologic changes and significantly prevented TGF-beta1 induced downregulation of E-cadherin and upregulation of collagen type I. Treatment with TSA did not alter TGF-beta1 induced phosphorylation of Smad2 and Smad3 but induced several inhibitory factors of TGF-beta1 signals, such as inhibitors of DNA binding/differentiation 2 ( Id2 ) and BMP-7
Choi et al., Invest Ophthalmol Vis Sci 2007 (Cataract) : Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells ... In addition, the TGFbeta1 mediated repression of E-cadherin was significantly inhibited by Slug siRNA ... These data suggest that TGFbeta1 induces Slug expression and that the repression of E-cadherin production by TGFbeta1 is mediated by the induction of Slug in lens epithelial cells
Buijs et al., Am J Pathol 2007 (Bone Neoplasms...) : Exogenous addition of BMP7 to human prostate cancer cells dose-dependently inhibited transforming growth factor beta induced activation of nuclear Smad3/4 complexes via ALK5 and induced E-cadherin expression
Maretzky et al., J Invest Dermatol 2008 (Blister...) : Proinflammatory cytokines, transforming growth factor-beta , and lipopolysaccharide led to increased release of soluble E-cadherin by activating mitogen activated protein kinase signaling in cultured keratinocytes
Li et al., Am J Pathol 2008 (Proteinuria) : TGF-beta1 suppressed the slit diaphragm associated protein P-cadherin , zonula occludens-1, and nephrin, a change consistent with loss of the epithelial feature
Tan et al., American journal of physiology. Renal physiology 2008 (Chronic Disease...) : Functionally, overexpression of Smurf2 enhanced the transcription of the TGF-beta-responsive promoter and augmented TGF-beta1 mediated E-cadherin suppression, as well as fibronectin and type I collagen induction in HKC-8 cells
Do et al., Mol Cancer Res 2008 (Neoplasm Metastasis...) : When cancer cells were cultured on plastic, TGF-beta1 , TGF-beta2, and TGF-beta3 induced pro-matrix metalloproteinase ( MMP ) secretion, loss of cell-cell junctions, down-regulation of E-cadherin , up-regulation of N-cadherin, and acquisition of a fibroblastoid phenotype, consistent with an epithelial-to-mesenchymal transition
Liu et al., Perit Dial Int 2008 (Fibrosis...) : Also, our results showed that SP600125 effectively suppressed TGFbeta1 induced high expression of alpha-SMA and collagen I, and prevented TGFbeta1 induced downregulation of E-cadherin expression in RPMCs
Dudas et al., Nephrol Dial Transplant 2009 : In RPTEC and HK-2 cells, TGF-beta1 significantly reduced e-cadherin expression and significantly increased vimentin, CTGF and TGF-beta1 expression
Sun et al., Zhonghua Bing Li Xue Za Zhi 2008 (Carcinoma, Squamous Cell...) : TGFbeta1-ASODN leads to an over-expression of E-cadherin and a down-regulation of vimentin, along with the morphological alterations and migration inhibition, indicating that a blockage of TGFbeta1 suppresses EMT in esophagus squamous cell carcinoma
Chen et al., Zhong Xi Yi Jie He Xue Bao 2009 : The expressions of alpha-smooth muscle actin ( alpha-SMA ) and E-cadherin were detected by two-color immunohistochemical staining, while the expressions of TGF-beta1 and ILK were detected by one-color immunohistochemical staining
Zheng et al., Am J Pathol 2009 (Fibrosis) : TGF-beta1 induced the proteolytic shedding of E-cadherin, which caused the nuclear translocation of beta-catenin, the transcriptional induction of Slug, and the repression of E-cadherin transcription in tubular epithelial cells
Leppäranta et al., Am J Respir Cell Mol Biol 2010 (Idiopathic Pulmonary Fibrosis) : In cultured A549 lung epithelial cells, the induction of GATA-6 by transforming growth factor-beta1 resulted in simultaneous expression of alpha-SMA and decrease of E-cadherin
Shi et al., Cancer Res 2009 (Lung Neoplasms) : Surprisingly, overexpression of IRS-1 in A549 cells completely blocked TGF-beta1 induced EMT and cell migration, inhibited TGF-beta1 mediated expression of snail and slug genes, and abolished TGF-beta1 mediated repression of E-cadherin promoter activity
Xu et al., Zhonghua Yi Xue Za Zhi 2009 : 3 ng/ml TGF-beta1 significantly up-regulated the mRNA and protein expression of alpha-SMA, reduced the expression of E-cadherin and increased the expression of CTGF after 48 h ( vs. control, P < 0.01 )
Deng et al., Mol Cell Biochem 2010 : TGF-beta1 induced down-regulation of E-cadherin was recovered by a PI3K/Akt inhibitor, LY294002, without affecting the expression of FAK
Hills et al., Mol Endocrinol 2010 : Further, effects of TGF-beta1 on Snail and E-cadherin expression were blocked by HGF, and inhibitory effects of C-peptide were removed by blockade of HGF activity
Zhou et al., Zhongguo Zhong Yao Za Zhi 2010 : BMP-7 significantly inhibited the down-regulation of E-cadherin and the up-regulation of alpha-SMA induced by TGF-beta1 ( P < 0.05 ), and SA-B significantly inhibited the up-regulation of alpha-SMA expression induced by TGF-beta1 ( P < 0.05 ), but not the down-regulation of E-cadherin induced by TGF-beta1