◀ Back to SMAD3
CREBBP — SMAD3
Pathways - manually collected, often from reviews:
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
p300/CBP/RELA/p50 complex (EP300-CREBBP-RELA)
(transcription, activates)
-
BioCarta tgf beta signaling pathway:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
p300/CBP complex (CREBBP-EP300)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
SMAD3/SMAD4/p300/CBP complex (EP300-CREBBP-SMAD3-SMAD4)
(modification, collaborate)
-
BioCarta tgf beta signaling pathway:
p300/CBP complex (CREBBP-EP300)
→
SMAD3/SMAD4/p300/CBP complex (EP300-CREBBP-SMAD3-SMAD4)
(modification, collaborate)
-
BioCarta nfkb activation by nontypeable hemophilus influenzae:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
p300/CBP/RELA/p50 complex (EP300-CREBBP-RELA)
(transcription, activates)
-
KEGG TGF-beta signaling pathway:
Complex of SMAD2-SMAD3-SMAD4
→
Complex of CREBBP-EP300-SP1
(protein-protein, activation)
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
Cbp/p300/Src-1 complex (EP300_CREBBP-NCOA1)
(modification, collaborate)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
Cbp/p300/Src-1 complex (EP300_CREBBP-NCOA1)
→
SMAD3/SMAD4/VDR complex (SMAD3-SMAD4-VDR)
(modification, activates)
Yanagisawa et al., Science 1999, Dennler et al., Oncogene 2005
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
Cbp/p300/PIAS3 complex (EP300_CREBBP-PIAS3)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, activates)
Long et al., Proc Natl Acad Sci U S A 2003, Long et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
Cbp/p300/SNIP1 complex (EP300_CREBBP-SNIP1)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, inhibits)
Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
SMAD3
—
CREBBP
Cui et al., Oncogene 2005*
-
IRef Bind_translation Interaction:
SMAD3
—
CREBBP
(coimmunoprecipitation)
Cui et al., Oncogene 2005*
-
IRef Bind_translation Interaction:
SMAD3
—
CREBBP
(affinity chromatography technology)
Cui et al., Oncogene 2005*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(physical association, affinity chromatography technology)
Kang et al., EMBO J 2005*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(physical association, affinity chromatography technology)
Alliston et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(direct interaction, pull down)
Chen et al., J Biol Chem 2007*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(direct interaction, two hybrid)
Nishihara et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(physical association, affinity chromatography technology)
Tomita et al., Oncogene 2004*
-
IRef Biogrid Interaction:
SMAD3
—
CREBBP
(physical association, affinity chromatography technology)
Xi et al., J Biol Chem 2008
-
MIPS CORUM RSmad complex:
RSmad complex complex (ARID1B-CREBBP-NCOA3-SMAD2-SMAD3-SMAD4-SMARCA4-SMARCC1-SMARCC2-TRIM33)
He et al., Cell 2006
-
MIPS CORUM CREBBP-SMAD3 hexameric complex:
CREBBP-SMAD3 hexameric complex complex (CREBBP-SMAD3)
Chen et al., J Biol Chem 2007*
-
MIPS CORUM CREBBP-SMAD3-SMAD4 pentameric complex:
CREBBP-SMAD3-SMAD4 pentameric complex complex (CREBBP-SMAD3-SMAD4)
Chen et al., J Biol Chem 2007*
-
IRef Corum Interaction:
Complex of 11 proteins
(association, affinity chromatography technology)
He et al., Cell 2006
-
IRef Corum Interaction:
SMAD3
—
CREBBP
(association, isothermal titration calorimetry)
Chen et al., J Biol Chem 2007*
-
IRef Corum Interaction:
SMAD3
—
CREBBP
(association, molecular sieving)
Chen et al., J Biol Chem 2007*
-
IRef Corum Interaction:
Complex of SMAD3-SMAD4-CREBBP
(association, molecular sieving)
Chen et al., J Biol Chem 2007*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Long et al., Proc Natl Acad Sci U S A 2004
-
IRef Hprd Interaction:
SMAD3
—
CREBBP
(in vitro)
Cui et al., Oncogene 2005*
-
IRef Hprd Interaction:
SMAD3
—
CREBBP
(in vivo)
Cui et al., Oncogene 2005*
Text-mined interactions from Literome
Hayashida et al., FASEB J 2003
(MAP Kinase Signaling System) :
These results indicate that
ERK dependent
R-Smad linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells
Dennler et al., Oncogene 2005
:
Such hypothesis was validated, as expression of a mutant form of SRC-1 lacking the CBP/p300 binding site failed to upregulate Smad3/4 dependent transcription, while full-length
SRC-1 potentiated
p300.Smad3 interactions
Ryoo et al., Gene 2006
:
The establishment of an in vitro model system has enabled the investigation of intracellular events including BMP receptor activation,
BMP-2 induced
R-Smad activation , and kinase activation, and the role of osteogenic transcription factors, such as Runx2, Osx, Dlx5, and Msx2
Inoue et al., Oncogene 2007
:
Moreover,
p300/CBP potentiated the transcriptional activity of GAL4-Smad3C, but not the acetylation-resistant
GAL4-Smad3C ( K378R ) mutant
Wang et al., Am J Physiol Heart Circ Physiol 2007
:
In I-Smad7 infected cells, we also observed the ablation of
TGF-beta(1) induced
R-Smad2 phosphorylation vs. LacZ controls
Zode et al., Glia 2009
(Glaucoma) :
Gremlin stimulation of
ECM required activation of TGF-beta receptor and
R-Smad3
Elshaier et al., Arthritis Rheum 2009
(MAP Kinase Signaling System) :
IL-1beta reduced the number of activin receptor-like kinase 2 (ALK-2) and ALK-3 receptors, inhibited expression of Smad1 and Smad6, delayed and prematurely terminated the onset of
OP-1 mediated
R-Smad phosphorylation, and affected nuclear translocation of R-Smad/Smad4 complexes
Murakami et al., Genes Cells 2009
:
Except for ALK4 and ALK6, levels of type I and type II receptor mRNAs were higher in B16 cells than in HeLa and HepG2 cells, in which TGF-beta1 and
BMP-2 induced phosphorylation of only the expected
R-Smad ... Except for ALK4 and ALK6, levels of type I and type II receptor mRNAs were higher in B16 cells than in HeLa and HepG2 cells, in which
TGF-beta1 and BMP-2
induced phosphorylation of only the expected
R-Smad
Fu et al., J Biol Chem 2009
:
This is the first evidence that
Notch activation
affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways
Yan et al., J Biol Chem 2009
:
Here, we provide evidence that human
BAMBI ( hBAMBI ), like its Xenopus homolog,
inhibits TGF-beta- and BMP mediated transcriptional responses as well as TGF-beta induced
R-Smad phosphorylation and cell growth arrest, whereas knockdown of endogenous BAMBI enhances the TGF-beta induced reporter expression
Cao et al., J Biol Chem 2010
:
Neuropilin-1 mediates divergent
R-Smad signaling and the myofibroblast phenotype
Park et al., PLoS Genet 2012
:
We propose a model whereby
DAF-8/R-Smad and NHR-69 negatively
regulate the transcription of
exp-2 to promote neuronal DAF-28 secretion, thus demonstrating a physiological crosstalk between TGF-ß and HNF4a-like signaling in C. elegans
Cheng et al., Chem Biol 2012
(MAP Kinase Signaling System) :
We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although
phospho-R-Smad levels were initially
stabilized by GSK3ß and
cyclin dependent kinase inhibition
Wang et al., J Immunol 2013
(Nephritis, Interstitial) :
Taken together, these data support a novel and direct
role for
NLRP3 in promoting TGF-ß signaling and
R-Smad activation in epithelial cells independent of the inflammasome
Layliev et al., Gene Ther 2013
:
R-SMAD nuclear translocation
increased Dlx5 and Pai1 transcription ...
R-SMAD nuclear translocation
increased Dlx5 and
Pai1 transcription
Shen et al., Mol Biol Cell 1998
:
TGF-beta induced phosphorylation of
Smad3 regulates its interaction with coactivator
p300/CREB binding protein