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EDN3 — HSPG2
Text-mined interactions from Literome
Mittmann et al., Naunyn Schmiedebergs Arch Pharmacol 2001
:
Additionally, both RGS proteins reduced basal and
endothelin stimulated
PLC activity in these membranes by about 40 %
Thomas et al., Am J Physiol 1991
:
The mechanisms of
stimulation of
phospholipase C (PLC) by
endothelin , specifically the role of guanine nucleotide binding proteins ( GTP binding proteins ) in coupling the endothelin receptor to PLC, were investigated in rat mesangial cells
Ambar et al., Eur J Pharmacol 1993
(Glioma) :
The
activation of
PLC or PLD by
endothelin in the three cell lines was mediated by the high affinity binding site ( nM range ) and was not significantly affected by either extracellular or intracellular Ca2+
Dokhac et al., J Cardiovasc Pharmacol 1995
:
In estrogen treated rat myometrium,
endothelin-1 (ET-1)
activated both the
phospholipase C (PLC) which degrades PtdInsP2, resulting in an increased accumulation of inositol phosphates, and the phospholipase D pathway ( PLD ) as evidenced in the presence of butanol by an increased production of phosphatidylbutanol ( PBut )
Matsumoto et al., Invest Ophthalmol Vis Sci 1996
(Second Messenger Systems) :
To characterize the pharmacology of
endothelin induced changes in
phospholipase C (PLC) activity, intracellular calcium concentration ( [ Ca2+ ] i ) and cyclic adenosine monophosphate ( cAMP ) in cultured human ciliary muscle ( HCM ) cells
Nord et al., Clin Exp Pharmacol Physiol 1996
:
5. Phosphatidylcholine-specific phospholipase C (
PC-PLC ) is
stimulated by
endothelin and accounts for the prolonged activation of diacylglycerol by this peptide
Haque et al., Curr Eye Res 1998
:
Similar results were obtained in HTM-3 cells : ET-1, but not
ET-3 or SRTX,
activated PLC in a dose dependent manner, with a calculated EC50 of 646 pM