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CREBBP — HNF4A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HNF4A → CREBBP (directlyIncreases, CREBBP Activity)
  Evidence: Fig.1- shows proteins that interact with CBP/300 Transciptional activators= STAT1, (already). SF1, TAL1, p73, Mdm2, HIF2?, ETS1, RXR, p65, Pit1 (POU1F1), HNF4, Stat2, EBNA2 (virus), HPV E2?, BRCA1, p45/NF-E2, c-JUN, c-myb, Tax?, Sap1, YY1, SREBP, ATF-1, ATF-4, Cubitus interuptusm GII3?, vIRF?, JMY, dMAD?, Py LT?, HPV E6, CIITA, Tat(HIV), SF-1, E2F, Ets-1, junB, C/EBPb, (already) GATA-1, Neuro D, Microphthalmia, E1A, Twist, p53 (already), Myo D, pp90 RSK, SMAD (already), ATF-2, c-Fos, SC40?, Lar...
• NCI Pathway Database HIF-1-alpha transcription factor network: HNF4 (HNF4A) → nucleus (EP300/CREBBP) (transcription, activates) Roth et al., J Biol Chem 2004
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HNF4A — CREBBP (physical association, affinity chromatography technology) Green et al., J Biol Chem 1998*
• IRef Biogrid Interaction: HNF4A — CREBBP (physical association, affinity chromatography technology) Yoshida et al., Biochem Biophys Res Commun 1997*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, pull down) Yoshida et al., Biochem Biophys Res Commun 1997*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, pull down) Dell et al., J Biol Chem 1999*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, pull down) Surapureddi et al., Mol Pharmacol 2008*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, enzymatic study) Soutoglou et al., Mol Cell 2000*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, pull down) Soutoglou et al., Mol Cell 2000*
• IRef Biogrid Interaction: HNF4A — CREBBP (direct interaction, two hybrid) Yoshida et al., Biochem Biophys Res Commun 1997*
• IRef Hprd Interaction: HNF4A — CREBBP (in vitro) Dell et al., J Biol Chem 1999*, Yoshida et al., Biochem Biophys Res Commun 1997*
• IRef Hprd Interaction: HNF4A — CREBBP (two hybrid) Dell et al., J Biol Chem 1999*, Yoshida et al., Biochem Biophys Res Commun 1997*
• IRef Ophid Interaction: CREBBP — HNF4A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005