◀ Back to HIF1A
CDH1 — HIF1A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CDH1
→
HIF1A
(decreases)
Evidence: HIF has recently been described as a critical factor for the regulation of E-cadherin expression in ovarian carcinoma and VHL-deficient renal cells.76,77 It has been proposed that HIF mediates repression of E-cadherin expression through the upregulation of E-cadherin-specific repressors, including Snail and SIP1.78
Text-mined interactions from Literome
Luo et al., BJU Int 2006
(Neoplasm Invasiveness...) :
The expression of
E-cadherin , vimentin, cathepsin D, MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be
regulated by
HIF-1alpha in human prostate cancer cells ... The expression of
E-cadherin , vimentin, cathepsin D, MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be
regulated by
HIF-1alpha in human prostate cancer cells
Cheng et al., Cancer Lett 2013
(Ovarian Neoplasms) :
Hypoxia-inducible factor 1 alpha mediates epidermal growth factor induced down-regulation of
E-cadherin expression and cell invasion in human ovarian cancer cells