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AR — PIK3R1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1) → T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src/PI3K complex (AR-PELP1-SRC-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Nongenotropic Androgen signaling: T-DHT/AR/PELP1/Src complex (AR-PELP1-SRC) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Castoria et al., J Cell Biol 2003
  Evidence: physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: AR — PIK3R1 (unknown, -) Sun et al., J Biol Chem 2003*

Text-mined interactions from Literome

Lu et al., Int J Oncol 2006 (Prostatic Neoplasms) : The purpose of this study is to investigate the role of PI3K-Akt signaling in prostate cancer cell growth and androgen receptor (AR) mediated gene expression
Zhu et al., Oncogene 2008 (Prostatic Neoplasms) : In our previous study, we found that inhibition of PI3K activity suppressed the androgen receptor (AR) mediated gene expression in prostate cancer cells
Liu et al., Prostate 2011 (Prostatic Neoplasms) : G-protein alpha-s and -12 subunits are involved in androgen stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells