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IL8 — TCF20
Text-mined interactions from Literome
Yamashita et al., Int Arch Allergy Immunol 1999
:
In that regard, the
transcription factor , nuclear factor, Kappa B ( NF-kappaB ), is an important
activator of tumor-necrosis-factor-alpha (TNF-alpha) induced
IL-8 gene expression in monocytes, lymphocytes and neutrophils
McDermott et al., Trends Mol Med 2002
(Familial Mediterranean Fever...) :
Disorders of
interleukin-1 processing and of
regulation of nuclear factor kappaB
transcription factor , and possibly defective apoptosis, might be involved in the pathogenesis of all but one of these disorders
Varney et al., In Vivo 2002
(Melanoma...) :
The differential expression of
IL-8 by monocytes following MCP-1 and M-CSF treatments
involved activation of the NFkB
transcription factor
Yeh et al., J Biol Chem 2004
(Inflammation) :
We have shown recently that Ox-PAPC mediated induction of
IL-8 transcription is
independent of NF-kappaB activation, a major
transcription factor utilized by cytokines and lipopolysaccharide for the induction of IL-8 transcription
Méndez-Samperio et al., Mediators Inflamm 2004
(Tuberculosis) :
In this study, our experiments were designed to determine the
role of the
transcription factor nuclear factor-kappaB (NF-kappaB) and intracellular calcium in the production of
interleukin (IL)-8 , a main chemotactic factor, by human derived monocytic cell line U937 and by a human epithelial HEp-2 cell line infected with M. bovis BCG
Tamaoki et al., Am J Med 2004
(Chronic Disease...) :
Macrolides
inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6,
IL-8 , and tumor necrosis factor-alpha, perhaps by suppressing the
transcription factor nuclear factor-kappaB or activator protein-1
Manna et al., J Biol Chem 2005
:
Interleukin-8 induces nuclear
transcription factor-kappaB through a TRAF6 dependent pathway
Zhou et al., J Clin Immunol 2004
:
IL-8 induction by hyperforin
required the activation of AP-1 but not the NF-kappaB
transcription factor , thereby distinguishing it from the NF-kappaB dependent IL-8 induction mediated by tumor necrosis factor alpha (TNFalpha)
Day et al., Dig Dis Sci 2004
(Helicobacter Infections) :
Interleukin-8 secretion was
inhibited following pretreatment of cells with anti-interleukin-18 antibody and by pharmacological inhibition of the nuclear
transcription factor , NF-kappaB
Tachado et al., J Leukoc Biol 2007
:
In human AM, Pc promoted direct interaction of MR and TLR2, IL-8 release was reduced markedly upon simultaneous blocking of TLR2 and gene silencing of MR, and
IL-8 release was
dependent in part on
transcription factor NF-kappaB and ERK1/2 and JNK MAPKs
Natarajan et al., Microvasc Res 2007
(Inflammation) :
Of major importance in the current report was the finding that hypoxia inducible factor-1 (HIF-1), a powerful
transcription factor mediating tissue responses to hypoxia, potently
regulated hemin induced
IL-8 secretion in human MVEC
Erkel et al., Int Immunopharmacol 2007
(Autoimmune Diseases...) :
Panepoxydone strongly
inhibited hTNF-alpha,
IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC ( 50 ) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB
transcription factor to the DNA
Qiao et al., Neoplasia (New York, N.Y.) 2007
(Neuroblastoma) :
Ets1
transcription factor mediates gastrin releasing peptide induced
IL-8 regulation in neuroblastoma cells
Vij et al., Am J Respir Cell Mol Biol 2008
(Cystic Fibrosis) :
CHOP
transcription factor mediates
IL-8 signaling in cystic fibrosis bronchial epithelial cells
Lemaire-Ewing et al., Cell Biol Toxicol 2009
(MAP Kinase Signaling System) :
Luciferase reporter gene assay using constructs of the human IL-8 gene promoter and Transam assay revealed the
involvement of the AP-1
transcription factor in oxysterol dependent
IL-8 secretion
Sheikh et al., Hepatology 2008
(Hepatitis C...) :
This
transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha),
interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand ... This
transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 6,
interleukin 8 , tumor growth factor beta, and Fas ligand
Chen et al., Immunity 2008
(Arthritis, Rheumatoid...) :
IRF-4 binding protein
inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4
transcription factor
Saraiva et al., Immunity 2009
:
Interleukin-10 production by Th1 cells requires
interleukin-12 induced STAT4
transcription factor and ERK MAP kinase activation by high antigen dose
Gerhard et al., Naunyn Schmiedebergs Arch Pharmacol 2011
:
Interleukin-8 (IL-8) ,
transcription factor c-jun and heme oxygenase-1 messenger RNA ( mRNA )
increased more than 2-fold
Rohr-Udilova et al., Hepatology 2012
(Carcinoma, Hepatocellular...) :
Activation of the activator protein 1 (AP-1)
transcription factor as well as increased serum levels of vascular endothelial growth factor ( VEGF ) and
interleukin (IL)-8 predict poor prognosis of patients with hepatocellular carcinomas (HCCs)
Lee et al., Oncol Res 2013
(Adenocarcinoma...) :
We investigated the
role of HGF induced activation of GRP and Ets-1
transcription factor in expression of the proangiogenic factor
IL-8
Sung et al., J Biol Chem 1993
:
Stimulation of
interleukin-1 gene transcription may be
caused by the stimulation of
transcription factor activities, including those of AP-1, by these protein phosphatase inhibitors
Wu et al., J Biol Chem 1997
:
In contrast to these three positive regulatory elements, the binding of the ubiquitously expressed POU-homeodomain
transcription factor , Oct-1, strongly
represses transcriptional activity of the
IL-8 promoter by binding independently to an element overlapping that of C/EBP