Randazzo et al., Science's STKE : signal transduction knowledge environment 2000
:
In addition to mediating Arf 's effects on membrane traffic and the actin cytoskeleton, PA and PIP2 are involved in the regulation of Arf Béglé et al., J Biol Chem 2009
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ARF6-siRNA greatly reduced secretagogue evoked phospholipase D ( PLD ) activation and phosphatidic acid formation at the plasma membrane and moderately reduced constitutive levels of PIP ( 2 ) present at the plasma membrane in resting cells
Martin et al., J Biol Chem 1996
:
Reduction of Arf translocation suppressed the increase in PLD and PIP kinase activities, whereas complete removal of Rho but not Arf from membranes with RhoGDI was without effect on PLD activity but increased PIP kinase activity