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CTNNB1 — HGF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
beta catenin (CTNNB1)
→
HGF complex (HGF)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
beta catenin (CTNNB1)
→
HGF(dimer)/MET(dimer) complex (MET-HGF)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF complex (HGF)
→
MET/beta catenin complex (MET-CTNNB1)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
MET/beta catenin complex (MET-CTNNB1)
→
HGF(dimer)/MET(dimer) complex (MET-HGF)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
HGF (HGF)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
HGF/MET complex (HGF-MET)
(modification, inhibits)
Qian et al., EMBO J 2004
Evidence: assay
Text-mined interactions from Literome
Davies et al., Anticancer Res 1999
(Neoplasm Invasiveness...) :
Using immunoprecipitation,
HGF/SF induced tyrosine phosphorylation of
beta-catenin but not desmoplakin
Noë et al., Biochem Soc Symp 1999
(Neoplasm Invasiveness) :
Scatter factor/hepatocyte growth factor ( SF/HGF ), on binding to its c-met tyrosine kinase receptor, can
induce invasion through tyrosine phosphorylation of
beta-catenin
Liu et al., FASEB J 2002
:
GSK-3beta phosphorylation was strongly correlated with reductions in both
HGF induced TER and enhanced
beta-catenin immunoreactivity observed at cell-cell junctions
Müller et al., Exp Cell Res 2002
(Carcinoma...) :
Hepatocyte growth factor (HGF) and epidermal growth factor (EGF)
induce beta-catenin signaling under conditions where they stimulate cell motility
Liou et al., Molecular vision 2002
:
HGF induced a MAP kinase dependent ARPE-19 cell migration, which is accompanied with a transient increase of c-jun expression and concomitant increases of MAP kinase activity, tyrosine phosphorylation of HGFR and beta-catenin,
increased cytosolic levels of
beta-catenin , and transactivation activity of beta-catenin
Dash et al., Cell Signal 2005
:
We also found that both
HGF treatment and pharmacological
activation of
beta-catenin leads to increased expression of inducible nitric oxide synthase (iNOS)
Zeng et al., Exp Cell Res 2006
:
HGF induced Met-beta-catenin dissociation and nuclear translocation of
beta-catenin , which was tyrosine-phosphorylation dependent ... All single or double-mutant transfected cells continued to show
HGF induced nuclear translocation of
FLAG-beta-catenin except the mutations affecting 654 and 670 simultaneously ( Y654/670F ), which coincided with the lack of formation of beta-catenin-TCF complex and DNA synthesis, in response to the HGF treatment ... In addition, the Y654/670F transfected cells also showed no phosphorylation of
beta-catenin or dissociation from Met in
response to
HGF ... Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in
HGF mediated
beta-catenin translocation, activation and mitogenesis
Peruzzi et al., Proc Natl Acad Sci U S A 2006
(Carcinoma, Renal Cell...) :
We show that reconstitution of VHL expression in RCC cells repressed
HGF stimulated
beta-catenin tyrosyl phosphorylation, adherens junction disruption, cytoplasmic beta-catenin accumulation, and reporter gene transactivation in RCC cells
Lee et al., Eur Surg Res 2007
(Adenocarcinoma...) :
The
effects of
HGF on the expression of
E-cadherin/beta-catenin and MMP-7 at both the protein and mRNA levels were assessed in stomach cancer cells, NUGC-3 and MKN-28, and in cells in which the expression of MMP-7 was downregulated by transfection with a MMP-7 short hairpin RNA plasmid
Lee et al., Am J Physiol Lung Cell Mol Physiol 2008
:
Inhibition of p42/p44 MAPK pathway blocked
HGF mediated activation of
beta-catenin gene transcription but not Akt activation, suggesting that p42/p44 MAPK acts in a parallel mechanism for beta-catenin activation
David et al., J Cell Sci 2008
:
However,
HGF , which also increases axon growth and branching,
induces beta-catenin phosphorylation at Y142 and a nuclear localization
Previdi et al., Eur J Cancer 2010
(Bone Neoplasms...) :
In 1833 cells, human and mouse
HGF increased Met and
beta-catenin tyrosine phosphorylation and expression in nuclear and perinuclear compartments, beta-catenin nuclear translocation via Kank and TOPFLASH transactivation
Hu et al., Anat Rec (Hoboken) 2010
(Ovarian Neoplasms) :
Our data indicated that
HGF leads to downregulation of E-cadherin,
beta-catenin , and caveolin-1, disassembly of cell-cell contacts, and invasion and migration enhancement in human ovarian cancer cells
Balkovetz et al., J Biol Chem 1997
:
We examined the
effects of
HGF on E-cadherin localization and interaction with
beta-catenin in polarized Madin-Darby canine kidney ( MDCK ) cell monolayers grown on filters ... Coimmunoprecipitation of beta-catenin/E-cadherin complexes showed that the amount of E-cadherin associated with beta-catenin increased during the first 24 h of HGF treatment with a return to baseline values after 48 and 72 h. Metabolic labeling showed that
HGF increased the synthetic rate of
beta-catenin and the amount of newly synthesized E-cadherin associated with immunoprecipitated beta-catenin, with the peak effect occurring after 12 h of treatment and returning to baseline after 24 h. HGF treatment inhibited transcytosis of immunoglobulin A by the polymeric immunoglobulin receptor
Papkoff et al., Biochem Biophys Res Commun 1998
:
WNT-1 and
HGF regulate GSK3 beta activity and
beta-catenin signaling in mammary epithelial cells ... Both Wnt-1 and
HGF/SF lead to nuclear accumulation of
beta-catenin and activation of a LEF/Tcf responsive reporter gene
Grisendi et al., J Cell Physiol 1998
:
The presence of
HGF during the calcium switch
caused increased tyrosine phosphorylation of
beta-catenin