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IRF5 — TLR4

Text-mined interactions from Literome

Takaoka et al., Nature 2005 (Inflammation...) : We also provide evidence that IRF-5 interacts with and is activated by MyD88 and TRAF6, and that TLR activation results in the nuclear translocation of IRF-5 to activate cytokine gene transcription
Abe et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : Statins inhibited TLR4 mediated activation of interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
Paun et al., J Biol Chem 2008 (Newcastle Disease) : IRF-5 is critical for TLR3-, TLR4- , and TLR9 dependent induction of TNFalpha in CD11c ( + ) dendritic cells
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses