Yuk et al., Immunol Cell Biol 2009
(Tuberculosis) :
Both TLR2 and TLR4 were required for optimal activation of ASK1 in response to M. bovis BCG
Ben Mkaddem et al., Cell Death Differ 2010
(Reperfusion Injury) :
These findings show that, concomitantly to the activation of p38, the gp96/TLR4 interaction is required for activation of ASK1/JNK signaling in posthypoxic mouse RTECs, and that the 28-kDa NOX4 has a key role in TLR4 mediated apoptosis during renal IRI