◀ Back to PTEN

PDPK1 — PTEN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PDPK1 → PTEN (decreases, PTEN Activity, PDPK1 Activity)
  Evidence: PKB phosphorylation and activity were reduced to the same extent as they were with PTEN expression. Finally we found that SHIP-2, like PTEN, caused a potent cell cycle arrest in G(1) in glioblastoma cells, which is associated with an increase in the stability of expression of the cell cycle inhibitor p27(KIP1) In these studies PtdIns(3,4,5)P3 and PtdIns(3,4)P2 were equally effective at allowing phosphorylation by PDK-1