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JUN — RSU1
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Masuelli et al., Cell Growth Differ 1999
:
Using Rsu-1 transfectants of the pheochromocytoma cell line PC12, we demonstrated previously that
Rsu-1 expression
inhibited Jun kinase activation but enhanced Erk2 activation in response to epidermal growth factor
Dougherty et al., Exp Cell Res 2005
:
Furthermore, RNAi induced reduction in Rsu-1 RNA and protein inhibited cell attachment, and while previous studies demonstrated that ectopic expression of Rsu-1 inhibited Jun kinase activation, the depletion of
Rsu-1 resulted in activation of
Jun and p38 stress kinases
Masuelli et al., Mol Cell Biol 1996
(Adrenal Gland Neoplasms...) :
Increased expression of the Ras suppressor
Rsu-1 enhances Erk-2 activation and
inhibits Jun kinase activation ... Transient expression of p33rsu-1 in Cos1 cells following cotransfection with either hemagglutinin tagged Jun kinase or hemagglutinin tagged Erk-2 revealed that
Rsu-1 expression
inhibited constitutive
Jun kinase activity while enhancing Erk-2 activity