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JUN — MIF

Text-mined interactions from Literome

Kleemann et al., Nature 2000 : MIF inhibits Jab1- and stimulus enhanced AP-1 activity, but does not interfere with the induction of the transcription factor NFkappaB ... Jab1 activates c-Jun amino-terminal kinase (JNK) activity and enhances endogenous phospho-c-Jun levels, and MIF inhibits these effects
Nguyen et al., J Immunol 2003 : Finally, overexpression of MIF inhibited phosphorylation of endogenous c-Jun induced by thiol starvation, indicating that MIF based suppression of apoptosis is mediated through modulation of c-Jun N-terminal kinase activity
Onodera et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : MIF enhanced AP-1 and NF-kappaB binding activities in a dose dependent manner
Burger-Kentischer et al., Atherosclerosis 2006 (Aortitis...) : Importantly, the local aortic expression of ICAM-1, MMP-2, TNF, IL-12, and CD40L was reduced by MIF blockade, as were the levels of the phospho-c-Jun and C/EBPbeta transcription factors
Verschuren et al., Circ Res 2009 (Atherosclerosis...) : In WAT, MIF deficiency reduces nuclear c-Jun levels and improves insulin sensitivity ; MIF deficiency also reduces macrophage accumulation in WAT and blunts the expression of two proteins that regulate macrophage infiltration ( intercellular adhesion molecule-1, CD44 )
Gesser et al., Inflamm Res 2011 (Psoriasis) : The effects of DMF on the MIF induced activation of MSK1, RSK1, cAMP-responsive element binding protein ( CREB ), Cox-2 and c-Jun , JunB and p53 were studied by Western blotting using phospho-specific antibodies