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PRL — PTPN11

Pathways - manually collected, often from reviews:

• Reactome Reaction: PRL → PTPN11 (indirect_complex)
• Reactome Reaction: PRL → PTPN11 (reaction)

Text-mined interactions from Literome

Fresno Vara et al., Mol Biol Cell 2001 : In contrast, they inhibited the PRL dependent stimulation of the SFKs substrate Sam68, the phosphorylation of the tyrosine phosphatase Shp2 , and the PI3K dependent Akt and p70S6k serine kinases
Chughtai et al., J Biol Chem 2002 : Furthermore, we demonstrate by nuclear co-immunoprecipitation and indirect immunofluorescence studies that PRL stimulation of mammary cells leads to the nuclear translocation of SHP-2 as a complex with Stat5a ... Finally, using the Stat5 GAS ( gamma activated sequence ) element of the beta-casein gene promoter in electrophoretic mobility shift assays, we demonstrate that PRL induces the SHP-2-Stat5a complex to bind to DNA