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EPHB2 — PTGS2

Text-mined interactions from Literome

Hirai et al., Thromb Haemost 1999 (MAP Kinase Signaling System) : These data indicate that PMA induced and PKC dependent expression of COX-2 requires mainly activation of ERK 1/2 among MAPKs, while activation of both ERK1/2 and p38 or possibly of all three families of MAPKs is necessary for vanadate induced and PTK dependent expression of COX-2
Wadleigh et al., J Biol Chem 2000 : In contrast, endotoxin induced COX-2 reporter activity is not blocked by overexpression of dominant negative forms of Raf-1, ERK1 , or ERK2
Subbaramaiah et al., J Biol Chem 2000 : Overexpressing dominant negative forms of ERK1 or p38 MAPK inhibited MIA mediated activation of the COX-2 promoter
Arbabi et al., Surgery 2000 : Inhibition of ERK activation had no effect on COX-2 expression
Newton et al., Biochem Biophys Res Commun 2000 : However, as ERK is not required for IL-1beta dependent induction of COX-2 , the mechanism of ceramide and SMase induction of COX-2 remains unclear
McGinty et al., Biochem J 2000 : The potential role of ERK in PGHS-2 up-regulation was assessed by using cell lines expressing, both stably and after adenoviral infection, constitutively active forms of its upstream activator MAPK/ERK kinase ( MEK1 )
Sheng et al., Cancer Res 2001 (MAP Kinase Signaling System) : Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2 , whereas inhibition of PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially blocked the induction of COX-2 by K-Ras
Guo et al., J Biol Chem 2001 (Cell Transformation, Neoplastic...) : Bombesin stimulation of COX-2 expression requires an increase in [ Ca ( 2+ ) ] ( i ), activation of extracellular signal regulated kinase ( ERK ) -1 and -2 and p38 ( MAPK ), and increased activation and expression of the transcription factors Elk-1, ATF-2, c-Fos, and c-Jun
Arbabi et al., J Surg Res 2001 (Carcinoma...) : Hyperosmolarity induced both p38 and ERK activation within 30 min ; however, only p38 inhibition attenuated osmotic induced COX-2 expression ; inhibition of ERK activation had no effect
Chen et al., Oncogene 2001 : Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes ... The roles of p38 MAP kinases and ERK in UVB induced cox-2 gene expression were studied in a human keratinocyte cell line, HaCaT
Park et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG induced cyclooxygenase-2 expression in Raw 264.7 cells
Fernández et al., Eur J Immunol 2002 : All of these stimuli were capable of activating the cells ; however, different patterns of response were observed as regards activation of the p42-MAP/ERK kinase, triggering of the NF-kappaB/Rel system, production of chemotactic cytokines, and induction of the expression of cyclooxygenase-2 (COX-2)
Mifflin et al., Am J Physiol Cell Physiol 2002 (Colitis) : Activation of nuclear factor-kappaB (NF-kappaB), extracellular signal regulated protein kinase ( ERK ), p38, and protein kinase C ( PKC ) signaling pathways was each necessary for optimal COX-2 induction
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Moon et al., Toxicological sciences : an official journal of the Society of Toxicology 2002 : Vomitoxin induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen activated protein kinases ... The ERK inhibitor PD98059 and p38 inhibitor SB203580 suppressed VT-induced PGE ( 2 ) and COX-2 protein expression, whereas impairment of JNK function by transient transfection with a dominant negative ( dn ) JNK vector had no effect on COX-2 protein expression
Brambilla et al., J Neurochem 2002 (Calcium Signaling...) : Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling
Zhao et al., American journal of physiology. Renal physiology 2003 : Pharmacological inhibition of ERK activation partially blocked tonicity dependent COX-2 expression
Choi et al., J Neurosci 2003 (Disease Progression...) : Inhibition of ERK1/2 and p38 MAPK reduced iNOS and COX-2 mRNA expression and rescued dopaminergic neurons in the SN
Kwon et al., Arch Pharm Res 2003 : Salicylate inhibited the IL-1beta and TNF-alpha induced COX-2 expressions, regulated the activation of ERK , IKK and IkappaB degradation, and the subsequent activation of NF-kappaB, in neonatal rat ventricular cardiomyocytes
Schmidt et al., J Gastrointest Surg 2003 (Adenocarcinoma...) : We investigated the effect of COX-2 inhibition on ERK-MAPK signaling and the effect of combining MEK ( MAPK kinase ) and COX-2 inhibitors in human hepatocellular carcinoma in vitro
Shen et al., Int J Cancer 2004 (Carcinoma, Squamous Cell) : PD98059, a specific ERK1/2 inhibitor, inhibited EGF induced proliferation with concomitant decreases in ERK1/2 phosphorylation and COX-2/PGE ( 2 ) induction
Grab et al., Biochim Biophys Acta 2004 : The ERK and p38 MAPKs can also stimulate the expression of both cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8)
Cui et al., Chem Phys Lipids 2004 : Involvement of ERK AND p38 MAP kinase in AAPH induced COX-2 expression in HaCaT cells ... Furthermore, we found that PD98059, an ERK pathway inhibitor, and SB203580, a p38 MAPK inhibitor, diminished AAPH induced COX-2 expression and PGE ( 2 ) production, whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH
Souza et al., Am J Physiol Gastrointest Liver Physiol 2004 (Adenocarcinoma...) : Acid induced activation of both ERK and p38 causes a significant increase in COX-2 promoter activity, and acid activated ERK stabilizes COX-2 mRNA
Chen et al., Biochim Biophys Acta 2004 (Carcinoma, Squamous Cell...) : EGF induced COX-2 promoter activity was inhibited by overexpression of the dominant negative forms of Ras and ERK2
Grishin et al., Surgery 2004 (Enterocolitis, Necrotizing) : ERK inhibition by U1026 enhanced endotoxin induced production of COX-2, consistent with negative regulation of COX-2 by ERK
Kim et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : These results suggest that IGF-II induces COX-2 expression through the tyrosine kinase-Src-ERK and tyrosine kinase-PI3-kinase pathways, but not via p38 MAPK pathway, and that the basal JNK activity is required for the upregulation of COX-2 by IGF-II, as well
Shin et al., Carcinogenesis 2004 (Adenocarcinoma...) : Consistent with our animal model, an in vitro study also demonstrated that incubation with nicotine ( 50-200 microg/ml ) for 5 h stimulated cell proliferation dose-dependently and increased COX-2 expression, prostaglandin E ( 2 ) ( PGE ( 2 ) ) and VEGF release, as well as activation of ERK phosphorylation
Slice et al., J Biol Chem 2005 : Inhibition of ERK activation by U0126 or PD98059 significantly decreased EGF dependent COX-2 expression, but did not affect Ang II-dependent COX-2 expression
Fukushima et al., Bone 2005 : IL-1alpha activated ERK phosphorylation and PD98059 greatly inhibited both COX-2 mRNA expression and PGE ( 2 ) production induced by IL-1alpha in PDL cells
Zhang et al., Brain Res 2005 (Anoxia) : Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen activated protein kinase ERK1/2
Du et al., Neoplasia (New York, N.Y.) 2005 : PD153035, an inhibitor of EGF receptor tyrosine kinase, and PD98059, an inhibitor of Erk , attenuated COX-2 expression in RIE and RIE-RhoA ( 63L )
Kanda et al., J Allergy Clin Immunol 2005 : The induction of COX-2 might be mediated by activation of p38 MAPK and ERK
Wang et al., Oncogene 2006 (Colonic Neoplasms) : Treatment with SB-216763 increased expression of cyclooxygenase-2 (COX-2) and IL-8, which are downstream targets of ERK1/2 activation ; this induction was abolished by MEK/ERK inhibition, suggesting GSK-3 inhibition induced COX-2 and IL-8 through ERK1/2 activation
Lee et al., Antioxid Redox Signal 2005 : Curcumin inhibits phorbol ester induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells ... Taken together, these findings suggest that curcumin inhibits the TPA induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential
Kang et al., FEBS Lett 2006 (Ovarian Neoplasms) : Using the specific inhibitors PD98059, AG1478 or dominant negative epidermal-growth-factor receptor ( EGFR-DN ) plasmid, we found that the activation of ERK1/2 played a role in Cox-2 induction, and the transactivation of EGFR worked as an upstream signaling pathway in ERK1/2 phosphorylation
He et al., Prostaglandins Leukot Essent Fatty Acids 2006 : Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes
Schmitz et al., J Clin Pathol 2006 (Breast Neoplasms) : The prognostic effect of COX-2 expression on lymph node negative breast cancer is confirmed-COX-2 is probably not regulated by HER-2, Akt, Erk1/2 or p38
Alique et al., Br J Pharmacol 2006 : Instead ATRA might act through a sustained activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) since up-regulation of COX-2 was prevented by inhibition of the activation of ERK1/2 with PD098059
Half et al., Cancer Lett 2007 (Colonic Neoplasms) : In conclusion, EGFR and ErbB-2 regulate ERK mediated COX-2 expression and their selective inhibition enhanced NS-398 induced cell death
Park et al., Biochem Biophys Res Commun 2007 : PKA, ERK , and p38 MAPK pathways regulate COX-2 mRNA expression induced by rolipram, in which PKA is a central regulator of the ERK and p38 MAPK pathways
Kim et al., Neuroscience 2007 : epsilonPKC activation increased ERK1/2 phosphorylation and COX-2 induction and conferred neuroprotection similar to IPC
Li et al., Lab Invest 2007 (Cardiomyopathy, Dilated...) : Inhibition of ERK activation, but not cyclooxygenase-2 inhibition , completely abolished beneficial effect of G-CSF on cardiac function
Cao et al., Cell Signal 2007 (MAP Kinase Signaling System...) : We showed that ERK1/2 and p38 MAPKs were required for IGF-I induced COX-2 expression and that activation of both pathways by IGF-I increased COX-2 transcriptional activation and its mRNA stability
Fichera et al., J Surg Res 2007 (Adenocarcinoma...) : In vitro, Ro26-2198 inhibited IL-1beta induced ERK activation and COX-2 induction and decreased HCA-7 cell proliferation
Wu et al., Mol Med 2007 (Neoplasm Recurrence, Local...) : We previously reported that the epidermal growth factor receptor (EGFR) is overexpressed in papilloma cells, that cyclooxygenase-2 (COX-2) is induced, and that COX-2 expression in primary papilloma cells requires activation of the EGFR but not Erk
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids potently stimulated COX-2 expression and induced AKT and ERK1/2 phosphorylation in concert with COX-2 induction ... Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Lin et al., Carcinogenesis 2008 (Brain Neoplasms...) : RV-induced ERK1/2 activation is involved in not only COX-2 expression but also nuclear COX-2 accumulation
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : On the other hand, Ox-LDL increased intracellular 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ) level through ERK1/2 dependent overexpression of COX-2 ... In conclusion, Ox-LDL induced increase in 15d-PGJ ( 2 ) level through ERK1/2 dependent COX-2 expression is one of the mechanisms of PPARalpha and PPARgamma activation in macrophages
Kim et al., J Cereb Blood Flow Metab 2008 : However, the intermediate pathway by which ERK1/2 activates COX-2 was not defined
Lin et al., J Cell Biochem 2008 (Head and Neck Neoplasms...) : Resveratrol induced nuclear COX-2 accumulation was dependent upon ERK1/2 activation, but not p53 activation
Milkiewicz et al., J Cell Physiol 2008 : This response was modulated by ERK1/2 and p38 MAP kinases, but was not dependent on NOS or COX-2 activity
Kim et al., Arch Pharm Res 2008 : Regulation of lysophosphatidic acid induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells ... Our data suggest that in esophageal epithelial cells, LPA induced COX-2 expression requires activation of PKC and ERK1/2 downstream of the LPA ( 1/3 ) receptor, Understanding the regulation of COX-2 expression induced by LPA in esophageal epithelial cells might provide a new therapeutic strategy for esophageal inflammatory diseases
Amaya et al., Pain 2009 (Disease Models, Animal...) : The COX-2 induction was prevented by ERK and p38 inhibitors
Wang et al., Inflamm Res 2009 (Chronic Disease...) : ERK and p38MAPK pathways were involved in signaling COX-2 through NF-kappaB pathway
Kim et al., Mol Cancer Res 2009 : COX-2 stimulates ERK phosphorylation via PGE2 ... This COX-2 induced ERK activation seems to increase ATR expression and activity in endogenous COX-2 overexpressing cancer cells as well as in COX-2 overexpressing stable cell lines
Kim et al., Mol Cancer Res 2009 : COX-2 induced activation of extracellular signal regulated kinase ( ERK ) and c-Jun NH ( 2 ) -terminal kinase ( JNK ) but suppressed Akt activation ... COX-2 may also regulate ERK activity independently of EGFR
Nah et al., Rheumatol Int 2010 (Arthritis, Rheumatoid) : EGF also stimulated ERK1/2 MAPK activity and the inhibition of ERK1/2 by PD098059 ( ERK1/2 specific inhibitor ) resulted in the suppression of EGF induced COX-2 expression
Lee et al., Cancer Res 2009 : Inhibition of arsenite induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression
Camalier et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Cell Transformation, Neoplastic...) : Supplementation of medium with phosphate increased anchorage independent transformation and proliferation of BALB/c mouse JB6 epidermal cells, activation of N-ras, ERK1/2 , and activator protein-1, and increased gene expression of Fra-1, COX-2 , and osteopontin in a dose dependent manner
El-Bikai et al., Arthritis Res Ther 2010 (Osteoarthritis) : It inhibited a1ß1 integrin and Col II expression as well as ERK1/2 and NF-?B-p65 phosphorylation, but, in contrast, markedly elicited PGE2 release, COX-2 expression and p38 MAPK phosphorylation
Galán et al., J Hypertens 2011 : Inhibition of either p38 MAPK ( SB203580 ) or ERK1/2 ( PD98059 ) reduced COX-2 and mPGES-1 expression in cells treated with IL-1ß or the combination of IL-1ß and Ang II
Cho et al., Mol Immunol 2011 : Pharmacologic inhibitors of ERK and p38 mitogen activated protein kinases inhibited the COX-2 upregulation
Küper et al., American journal of physiology. Renal physiology 2012 : In conclusion, these results propose that LPS mediates enhanced COX-2 expression in IMCD cells by 1 ) TLR4 mediated activation of the NF-?B signaling pathway, 2 ) TLR4 dependent release of TGF-a with subsequent activation of the EGFR and downstream MAPKs p38 and ERK1/2 , and 3 ) TLR4 mediated, EGFR independent activation of JNK that negatively regulates NF-?B activation
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : Although PAR(2) activation increased ERK MAPK phosphorylation, neither ERK pathway inhibitors nor a p38 MAPK inhibitor affected 2fLI induced COX-2 expression
Lee et al., Particle and fibre toxicology 2012 (MAP Kinase Signaling System) : MWCNTs caused ERK1,2 activation and inhibition of ERK1,2 ( U0126 ) blocked MWCNT induction of COX-2 and PGE2 production, but did not reduce the induction of iNOS ... Furthermore, our work demonstrates that COX-2 induction by MWCNTs in RAW264.7 macrophages is ERK1,2 dependent , while iNOS induction by MWCNTs is ERK1,2 independent
Chen et al., PloS one 2012 (Inflammation...) : Surprisingly, COX-2 expression in proliferative cells was not blocked by PKCd or ERK1/2 inhibitors due to intrinsic inhibition of PKCd and ERK1/2 in proliferative cells
Tsai et al., J Dermatol Sci 2013 (Gram-Positive Bacterial Infections...) : ROS dependent stimulation of ERK , JNK, NF-?B, and AP-1 activation contributes to P. acnes induced iNOS/NO and COX-2/PGE ( 2 ) in macrophages, and chemicals such as hispolon possessing ability to block iNOS/NO and COX-2/PGE ( 2 ) production reserve potential to be further developed for treatment of the early phase of inflammation elicited by P. acnes
Wang et al., Toxicol In Vitro 2013 : Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK , p38 and JNK
Sheng et al., J Biol Chem 1998 : Inhibition of ERK activity by PD 98059 also suppressed the induction of COX-2 by epidermal growth factor in intestinal epithelial cells and significantly reduced the expression of COX-2 in Ha-Ras transformed rat intestinal epithelial cells
Niiro et al., Biochem Biophys Res Commun 1998 : The induction of COX-2 mRNA, COX-2 protein, and prostaglandin ( PG ) E2 by LPS was inhibited by the specific inhibitors of ERK and p38 MAPK, suggesting that the activation of ERK2 and p38 MAPK is involved in COX-2 expression in LPS stimulated monocytes
Adderley et al., J Biol Chem 1999 : In cardiomyocytes cell injury by H2O2 and doxorubicin is limited by an increase in prostacyclin formation that reflects induction of COX-2 mediated by ERK1/2 activation