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EPHB2 — PEBP1

Text-mined interactions from Literome

Yeung et al., Nature 1999 (Cell Transformation, Neoplastic) : Downregulation of endogenous RKIP by expression of antisense RNA or antibody microinjection induces the activation of MEK-, ERK- and AP-1 dependent transcription
Schuierer et al., Oncol Rep 2006 (Carcinoma, Hepatocellular...) : In contrast, downregulation of RKIP by transfection with an antisense RKIP construct led to increased ERK1/2 and AP-1 activity
Petrov et al., IET Syst Biol 2007 (MAP Kinase Signaling System) : Analytical solutions, relating the steady-state values of the fast varying protein concentrations and the slow varying ones, are derived and interpreted as restrictions on the regulatory role of RKIP on ERK-pathway
Houben et al., Journal of carcinogenesis 2007 : Surprisingly the absence of phosphorylation of the MAP kinases ERK1 and ERK 2 even following growth factor stimulation was not affected by the RKIP knock down indicating that RKIP is not essential for blocking the MAP kinase pathway in the MCC cell line UISO
Ma et al., Liver Int 2009 : Raf kinase inhibitor protein inhibits ERK/MAPK signalling and this inhibition impedes HSC proliferation
Eves et al., Methods Mol Biol 2010 : As demonstrated by immunofluorescence at kinetochores, depletion of Raf Kinase Inhibitory Protein (RKIP) , an inhibitor of Raf/MEK/ERK signaling, causes an increase in MAPK activity that inhibits Aurora B kinase activity
Al-Mulla et al., PloS one 2012 (Colorectal Neoplasms) : RKIP has been shown to inhibit the Raf-MEK-ERK , NF?B, GRK and activate the GSK3ß signaling pathways
Antoun et al., J Neurosci 2012 (MAP Kinase Signaling System) : Overexpression of a nonphosphorylatable form of RKIP in the SCN of transgenic mice blocks light induced ERK1/2 activation in the SCN and severely dampens light induced phase delays in behavioral rhythms ... Collectively, our data reveal an important role of RKIP in the regulation of MAPK/ERK signaling in the SCN and photic entrainment of the SCN clock
Kim et al., Endocr Res 2013 (Adenocarcinoma, Papillary...) : The aims of this study were to evaluate the activation status of extracellular signal regulated kinase 1/2 ( ERK1/2 ) in human PTCs with BRAF ( V600E ) mutations compared to that of corresponding normal thyroid tissue and to determine the expressions of Raf kinase inhibitor protein (RKIP) and MAPK phosphatase 3 (MKP-3), possible regulators of ERK1/2 activation
Lee et al., Neoplasia (New York, N.Y.) 2013 : Through several molecular biologic analyses, we found that RKIP , an inhibitor of Raf kinase, is responsible for p53 mediated ERK suppression and senescence