Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Tsang et al., J Leukoc Biol 2005 (Inflammation...) : Results indicated that SCF activated ERK , and TNF-alpha activated the p38 MAPK and NF-kappaB pathway ... Therefore, SCF and TNF-alpha acted through ERK and the NF-kappaB pathway to regulate the ICAM-1 expression and elicited the synergistic effect
Khanzada et al., Oncogene 2006 (Carcinoma, Small Cell...) : These responses correlated with the inhibition of stem cell factor (SCF) stimulated activation of extracellular signal regulated kinase ( Erk ), protein kinase B (PKB) and ribosomal S6 kinase by simvastatin
Wong et al., Allergy 2006 : The induction of RANTES by SCF or TNF-alpha was mediated by ERK and NF-kappaB, respectively, and SCF induced MIP-1beta release was mediated by ERK
Rådinger et al., J Immunol 2011 : The decrease in stem cell factor (SCF) mediated survival in the GSK3ß knockdown HuMCs was reflected by enhancement of SCF withdrawal induced apoptosis, as determined by Annexin V staining and caspase cleavage, and this was associated with a pronounced reduction in SCF mediated phosphorylation of Src homology 2 domain containing phosphatase 2 and ERK1/2 and reduced expression of the antiapoptotic proteins Bcl-xl and Bcl-2