◀ Back to IFNG
IFNG — JAK2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
JAK2
→
IFNG
(increases, IFNG Activity)
Kota et al., J Biol Chem 2005*
Evidence: Although LPL alone had no effect on Stat1 activation, LPL enhanced IFN-gamma-induced phosphorylation of Stat1 on tyrosine 701 and serine 727, as well as Stat1-mediated transactivation. The synergistic effect of LPL on IFN-gamma-induced Stat1 activation was mediated by enhanced activation of the tyrosine kinase JAK2 and was abrogated by LY294002, a specific inhibitor of the phosphatidylinositol 3'-kinase pathway.
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2)
→
TID1 (DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
TID1 (DNAJA3)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A)
→
IFN-gamma (IFNG)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma (IFNG)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
HSP70 (HSPA1A)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1)
→
IFN-gamma (IFNG)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma (IFNG)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG)
(modification, collaborate)
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
MEKK1 (MAP3K1)
(modification, activates)
Roy et al., Proc Natl Acad Sci U S A 2002
Evidence: mutant phenotype
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database SHP2 signaling:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma (dimer) complex (IFNG)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2)
→
IFN-gamma (dimer) complex (IFNG)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
TCPTP p45 (PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2)
→
TCPTP p45 (PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CBL (CBL)
(modification, activates)
Alsayed et al., J Immunol 2000
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CaM/Ca2+/CAMKII complex (CALM2-CAMK2A_CAMK2B_CAMK2D_CAMK2G)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
Ca2+/CaM complex (CALM2)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CaMKII family (CAMK2A/CAMK2B/CAMK2D/CAMK2G)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
None
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
STAT1 (STAT1)
(modification, activates)
Shuai et al., Science 1992*, Igarashi et al., J Biol Chem 1994, Shuai et al., Science 1993, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Nguyen et al., J Biol Chem 2001, Deb et al., J Immunol 2003
Evidence: mutant phenotype
-
NCI Pathway Database IL23-mediated signaling events:
IFN-gamma (IFNG)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, inhibits)
Langrish et al., J Exp Med 2005, Harrington et al., Nat Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SOCS1 (SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
SOCS1 (SOCS1)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
MAP3K11 (MAP3K11)
(modification, activates)
Roy et al., J Biol Chem 2005
Evidence: mutant phenotype
-
Reactome Reaction:
IFNG
→
JAK2
(indirect_complex)
Thiel et al., Structure 2000*, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Kotenko et al., J Biol Chem 1995*, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997
-
Reactome Reaction:
IFNG
→
JAK2
(reaction)
Thiel et al., Structure 2000*, Aaronson et al., Science 2002, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Quelle et al., J Biol Chem 1995, Kotenko et al., J Biol Chem 1995*, Shuai et al., Science 1993, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997
Text-mined interactions from Literome
Nomura et al., Toxicol Lett 1998
(Ischemic Attack, Transient) :
LPS caused intranuclear translocation of NF-kappaB, and
IFNgamma induced phosphorylation of
Jak2 and Stat1, followed by the translocation of Stat1 into the nucleus
Caldenhoven et al., J Leukoc Biol 1999
:
Binding of
interferon-gamma (IFN-gamma) to its heterodimeric receptor
induces activation of the tyrosine kinases JAK1 and
JAK2 followed by tyrosine phosphorylation of STAT1alpha
Lian et al., Cell Immunol 1999
:
Immunoprecipitation and Western blot analyses indicated that
IFN-gamma induced phosphorylation of Stat1 and
Jak2 was blocked by dextran sulfate
Li et al., Oncogene 1999
:
Here we show that expression of the ` malignant ' HPV-18 E6 in human HT1080 cells results in inhibition of
Jak-STAT activation in
response to IFN-alpha but not
IFN-gamma
Ochiai et al., Clin Exp Immunol 1999
:
Further,
IFN-gamma induced tyrosine phosphorylation of
JAK2 in eosinophils, as indicated by Western blot analysis ... In conclusion, these results indicate that
IFN-gamma induces eosinophil survival and CD69 expression through the activation of
JAK2 in peripheral eosinophils, suggesting that JAK2 may play a significant role in eosinophil regulation by IFN-gamma-IFN-gammaR interaction
Nomura et al., Nihon Yakurigaku Zasshi 1999
(Glioma...) :
p65 ) and 3 )
IFN gamma induced autophosphorylation and
activation of
Jak 2 and Stat 1 as well as intranuclear translocation of phosphorylated Stat 1
Sakamoto et al., Leukemia & lymphoma 2000
:
This resistance was caused by inhibition of JAK1 and
JAK2 activation in
response to
IFNgamma
Nguyen et al., Biochem J 2000
:
Here, we report that IFN-alpha/beta and
IFN-gamma rapidly
activate the
JAK-STAT1 ( Janus kinase-signal transducer and activator transcription factor 1 ) and p42/44 mitogen activated protein kinase ( p42/44 MAPK ) in freshly isolated rat hepatocytes
Iwamoto et al., Oncogene 2000
(Acute-Phase Reaction) :
Furthermore, in vitro kinase assay indicated that JAB suppressed hyperactivation of
JAK1/JAK2 and JAK1
induced by
IFNgamma and IL-6 plus sIL-6R respectively, but not v-Src induced basal JAK1/JAK2 activity
Cottet et al., J Biol Chem 2001
(Diabetes Mellitus, Type 1) :
SOCS-1 protein prevents
Janus Kinase/STAT dependent inhibition of beta cell insulin gene transcription and secretion in
response to
interferon-gamma
Kim et al., Mol Pharmacol 2001
:
These effects inhibit full activation of the
IFN-gamma induced
Janus kinase ( JAK ) /STAT signaling pathway in FRTL-5 thyroid cells
Srisatjaluk et al., Infect Immun 2002
:
Consequently,
IFN-gamma induced phosphorylation of Jak1,
Jak2 , and Stat1 alpha proteins was prevented
Osaki et al., Biochem J 2003
:
Our results indicate that repression of COL2A1 gene transcription by
IFN-gamma requires Jak1,
Jak2 and Stat1 alpha and suggest that this response involves indirect interaction of activated Stat1 alpha with the general transcriptional machinery that drives constitutive COL2A1 expression
Sugimoto et al., Eur J Immunol 2003
:
Differential
requirements for
JAK2 and TYK2 in T cell proliferation and
IFN-gamma production induced by IL-12 alone or together with IL-18 ... Using two JAK inhibitors, tyrphostin A1 ( A1 ) for TYK2 and tyrphostin B42 ( B42 ) for JAK2, we investigated the
involvement of
JAK2 and TYK2 in IL-12 induced T cell proliferation and
IFN-gamma production
Blanchette et al., Immunology 2003
(Translocation, Genetic) :
To determine whether the inhibitory effect was taking place at the pre- and/or post-transcriptional level, we evaluated the effect of each antagonist on inducible nitric oxide synthase (iNOS) gene and protein expression, and on the capacity of
IFN-gamma to
induce JAK2 , Erk1/Erk2 and STAT1alpha phosphorylation
Hu et al., J Immunol 2003
:
We investigated whether GCs could also block
activation of
Janus kinase-STAT signaling by
IFN-gamma , a potent proinflammatory cytokine
Klampfer et al., Mol Cancer Res 2003
:
IFN-gamma induced
JAK2 activation was inhibited by butyrate, implicating JAK2 as a target of butyrate action
Jaramillo et al., J Immunol 2003
(MAP Kinase Signaling System) :
Even though selective inhibition of the Janus kinase 2/STAT1alpha pathway suppressed NO synthesis in response to HZ + IFN-gamma, HZ alone did not activate this signaling pathway and did not have an up-regulating effect on the
IFN-gamma induced
Janus kinase 2/STAT1alpha phosphorylation and STAT1alpha binding to the iNOS promoter
Kato et al., Br J Haematol 2003
:
IFN-gamma activates Jak1 and
Jak2 , followed by the activation of Stat1
Imai et al., FEMS Immunol Med Microbiol 2003
:
Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits
IFN-gamma stimulated
JAK/STAT signaling in J774 macrophages
Chang et al., Mol Pharmacol 2004
:
Tyrosine phosphorylation of
Janus kinases (JAK) 1/2 was
induced by
IFN-gamma but not by TPA
Jaramillo et al., J Immunol 2004
(MAP Kinase Signaling System) :
Characterization of the second messengers involved revealed the requirement of
IFN-gamma mediated
Janus kinase 2/STAT1 alpha
activation even though MSU crystals did not modulate this signaling cascade by themselves
Huang et al., Mol Pharmacol 2004
:
LPS activated p38 mitogen activated protein kinase ( MAPK ), whereas
IFNgamma activated
Janus kinase and signal transducer and activator of transcription-1 ( STAT1 )
Qing et al., J Biol Chem 2005
:
Mutation of Tyr ( 441 ) also blocked the ability of SOCS-1 to bind to IFNGR1 and
JAK2 in
response to
IFNgamma and the normal down-regulation of STAT1 activation and antiviral activity
Saile et al., Eur J Cell Biol 2004
:
However
IFN-gamma had no effect on upregulation of
JAK-2 and pJAK-2 by IFN-alpha
Bhardwaj et al., Int J Parasitol 2005
:
We found that both L. major and L. mexicana suppressed IFNgammaRalpha ( alpha subunit of interferon gamma receptor ) and IFN-gammaRbeta ( beta subunit of interferon gamma receptor ) expression, reduced levels of total Jak1 and Jak2, and down-regulated
IFN-gamma induced Jak1,
Jak2 and STAT1 activation
Choi et al., Biochem Biophys Res Commun 2005
(Inflammation) :
Anti-inflammatory roles of retinoic acid in rat brain astrocytes : Suppression of
interferon-gamma induced
JAK/STAT phosphorylation ... Both RA isoforms also reduced
IFN-gamma induced activation of signal transducers and activators of transcription ( STAT ) 1, STAT3,
Janus kinase (JAK)1, and JAK2
Kaur et al., J Neurochem 2005
:
Treatment of neurons with H ( 2 ) O ( 2 ) and rotenone also inhibited
interferon-gamma mediated
activation of
Jak/STAT1
Kulka et al., J Pharmacol Exp Ther 2005
:
IFNgamma up-regulation of CFTR in mast cells was
inhibited by p38 and extracellular signal regulated kinase ( ERK ) kinase inhibitors but not a
Janus tyrosine kinase (JAK)2 inhibitor, whereas in T84 cells IFNgamma mediated down-regulation of CFTR was JAK2 dependent and ERK- and p38 independent
Ehrhart et al., Journal of neuroinflammation 2005
:
In addition, this CB2 agonist markedly inhibited
IFN-gamma induced phosphorylation of
JAK/STAT1
Steiner et al., J Cell Sci 2006
(Lung Neoplasms) :
Summarizing, we identify MVP as an IFN-gamma-responsive gene interfering with
IFN-gamma activated
JAK/STAT signals
Brzózka et al., J Virol 2006
:
We here show that RV P in addition is responsible for preventing IFN-alpha/beta- and
IFN-gamma stimulated
JAK-STAT signaling in RV-infected cells by the retention of activated STATs in the cytoplasm
Leon et al., J Immunol 2006
:
In 293T cells with reduced expression of AxV, brought about by small interfering RNA targeting, activation of
Jak2 and Stat1alpha in
response to
IFN-gamma was enhanced
Nagineni et al., J Cell Physiol 2007
:
JAK inhibitor selectively inhibited IFN-gamma
induced TGF-beta1 secretion and mRNA levels while reversing the inhibitory effects of
IFN-gamma on TGF-beta2
Cho et al., Glia 2007
(Alzheimer Disease...) :
Taken together, our results suggest that
IFN-gamma activates
JAK2 and ERK1/2 and then phosphorylated STAT1 binds to the putative STAT1 binding sequences in BACE1 promoter region to modulate BACE1 protein expression in astrocytes
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Prolactin induced phosphorylation of JAK2 and ERK, whereas
IFN-gamma induced phosphorylation of JAK1,
JAK2 , and p38 MAPK ... Prolactin modestly or
IFN-gamma greatly induced tyrosine phosphorylation of STAT1, and both were
suppressed by
JAK inhibitor
Vidy et al., J Virol 2007
:
Rabies virus P protein inhibits alpha interferon ( IFN-alpha ) - and
IFN-gamma stimulated
Jak-STAT signaling by retaining phosphorylated STAT1 in the cytoplasm
Park et al., Mol Immunol 2007
(MAP Kinase Signaling System) :
We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting
IFN-gamma 's induction of T-bet and other Th1 differentiation genes, and that TGF-beta1
inhibits receptor-proximal
IFN-gamma-Jak-Stat signaling responses
Watling et al., Proc Natl Acad Sci U S A 2008
(Neoplasms) :
JAK/STAT signaling is not, however,
sufficient for a full
IFN-gamma response
Whiteman et al., Journal of inflammation (London, England) 2008
:
This differential effect on HRV-14 receptor isoforms appears to be related to a combination of decreased
IFN-gamma induced
JAK-STAT signalling and proteolytic receptor cleavage of the membranous form in IFN-gamma biased HRV-14 infected cells
Panzer et al., Nephrol Dial Transplant 2008
(Glomerulonephritis) :
Combined results from EMSA and western blot analysis revealed the inhibitory ability of 15d-PGJ ( 2 ), but not of synthetic PPARgamma ligands, on
IFN-gamma induced tyrosine phosphorylation of JAK1,
JAK2 , STAT1 and nuclear STAT1 translocation and DNA binding
Gira et al., J Invest Dermatol 2009
(Anoxia) :
Iron chelators and hypoxia mimetics inhibit
IFNgamma mediated
Jak-STAT signaling
Kar et al., Eur J Immunol 2009
(Disease Models, Animal...) :
DNA binding as well as silencing experiments revealed the requirement of
IFN-gamma mediated
JAK-STAT activation even though cystatin did not modulate this signaling cascade by itself
Yu et al., J Biol Chem 2009
:
IFN-gamma enhanced the association between
JAK2 and ASK1, and the ASK1-JAK2 complex was labile and was stabilized by the proteasomal inhibitor MG132
Qi et al., J Cell Physiol 2009
:
IFN-gamma induced phosphorylation of JAK1 and
JAK2 , whereas TNF-alpha induced phosphorylation of ERK1/2
Wu et al., Br J Pharmacol 2009
:
Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity,
activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and
Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) +
interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma ... LPS +
IFNgamma stimulated phosphorylation of ERK, JNK and
Jak2 , and degradation of IkappaB, but only Jak2 phosphorylation was sensitive to tripterine ( 50-200 nM )
Simmons et al., J Virol 2009
:
Furthermore, at times when STAT1 activation was efficiently inhibited, VRP infection did not limit tyrosine phosphorylation of Jak1, Tyk2, or STAT2 after IFN-beta treatment but did inhibit Jak1 and
Jak2 activation in
response to
IFN-gamma , suggesting that VEEV interferes with STAT1 activation by the type I and II receptor complexes through distinct mechanisms
Park et al., Mol Cells 2010
:
These results indicate that
JAK/Stat1 mediated
IFN-gamma signaling antagonizes TGF-beta1 induced GL alpha transcription, mainly through deprivation of p300 from Smad3, resulting in decreased IgA synthesis
Valmas et al., PLoS Pathog 2010
(Hemorrhagic Fever, Ebola...) :
Global loss of STAT and
Jak tyrosine phosphorylation in
response to both IFNalpha/beta and
IFNgamma is reminiscent of the phenotype seen in Jak1-null cells
Chang et al., J Biol Chem 2010
(Inflammation) :
Autophagy facilitates
IFN-gamma induced
Jak2-STAT1 activation and cellular inflammation
Silva et al., J Biol Chem 1994
:
We provide two lines of evidence that the JAK2 kinases can be regulated independently by GH and IFN gamma in IM-9 cells : 1 ) desensitization of
JAK2 to GH stimulation does not
affect the
IFN gamma stimulated tyrosine phosphorylation of JAK2 ; and 2 ) JAK2 tyrosine phosphorylation by GH and IFN gamma is additive to that seen with either hormone alone
Musso et al., J Exp Med 1995
:
In contrast,
JAK3 expression was strongly
induced during activation by
interferon gamma (IFN-gamma) or lipopolysaccharide
King et al., Endocrinology 1995
:
Dexamethasone does not inhibit induction of tyrosyl phosphorylation of ERK proteins by epidermal growth factor or phorbol myristate acetate, nor does it block induction of tyrosyl phosphorylation of Stat3/APRF by leukemia inhibitory factor or interleukin-6, or
induction of
JAK2 by leukemia inhibitory factor or
interferon-gamma
Panek et al., J Immunol 1995
:
TGF-beta suppression of IFN-gamma induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1,
JAK2 , or signal transducers and activators of transcription, or modification of
IFN-gamma enhanced factor X expression
Watling et al., Nature 1993
:
Unlike IFNs alpha and beta,
IFN-gamma induces rapid tyrosine phosphorylation of
JAK2 in wild-type cells, and JAK2 immunoprecipitates from these cells show tyrosine kinase activity
Novak et al., Growth Factors 1996
:
Instead of increased phosphorylation of JAK1 and
JAK2 in
response to G-CSF and
interferon-gamma , and JAK1 and Tyk2 in response to interferon-alpha/beta, we observed only an increase of phosphorylation of Tyk2 in response to all of these cytokines in NFS-60 cells
Kohlhuber et al., Mol Cell Biol 1997
:
Conversely, a JAK1-JAK2 chimera with the amino-terminal domains of JAK1 linked to the pseudokinase and kinase domains of JAK2 is capable of reconstituting
JAK-STAT signalling in
response to
IFN-alpha and -gamma in mutant U4C cells lacking JAK1
Nandan et al., J Immunol 1997
:
In contrast, TGF-beta did not affect
IFN-gamma induced tyrosine phosphorylation of Jak1,
Jak2 , or the signal transducer and activator of transcription-1 ( Stat1 )
Aragane et al., Proc Natl Acad Sci U S A 1997
:
STAT1 is a cytoplasmic transcription factor that is phosphorylated by
Janus kinases ( Jak ) in
response to
interferon-gamma (IFNgamma)
Lee et al., Infect Immun 1998
:
To test whether ehrlichial infection disrupts
Janus kinase ( Jak ) and signal transducer and activator of transcription ( Stat ) signaling
induced by
IFN-gamma , tyrosine phosphorylation of Stat1, Jak1, and Jak2 in E. chaffeensis infected THP-1 cells was examined by immunoprecipitation followed by immunoblot analysis ... Viable E. chaffeensis organisms blocked tyrosine phosphorylation of Stat1, Jak1, and
Jak2 in
response to
IFN-gamma within 30 min of infection ... These results suggest that E. chaffeensis blocks
IFN-gamma induced tyrosine phosphorylation of
Jak and Stat through raising PKA activity in THP-1 cells, which may be an important survival mechanism of ehrlichiae within the host cell
Sakamoto et al., Blood 1998
(Leukemia, Myeloid) :
Moreover,
IFN-gamma induced activation of JAK1 and
JAK2 and IFN-beta induced JAK1 and Tyk2 activation were inhibited in NIH-3T3 JAB transformants