Yuan et al., Amino Acids 2008
(MAP Kinase Signaling System) :
TIMP-3 treatment induced p38 and ERK phosphorylation
Chetty et al., Cancer Res 2008
(Lung Neoplasms...) :
TIMP-3 induction was mediated by ERK activation
Leivonen et al., PloS one 2013
(MAP Kinase Signaling System) :
Specific activation of p38a and ERK1/2 by constitutively active mutants of MKK3b or MEK1, respectively, and simultaneous co-expression of Smad3 resulted in induction of TIMP-3 expression in the absence of TGF-ß indicating that Smad3 co-operates with p38 and ERK1/2 in the induction of TIMP-3 expression