Gene interactions and pathways from curated databases and text-mining

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EPHB2 — KCNH8

Text-mined interactions from Literome

Kelemen et al., J Biol Chem 2002 (MAP Kinase Signaling System) : In addition, cell-permeable peptides inhibited ERK mediated activation of the transcriptional activity of ELK1
Koncz et al., Immunol Lett 2002 : We compared the BCR induced intracellular [ Ca2+ ] transient, protein tyrosine phosphorylation and ERK phosphorylation, furthermore, the activation of Elk-1 and CREB transcription factors
Adiseshaiah et al., J Immunol 2006 (MAP Kinase Signaling System) : ERK inhibition not only blocked phosphorylation of Elk1 , CREB, and ATF1, which constitutively bind to the FRA-1 promoter, but also suppressed the recruitment of c-Jun to the promoter ... Our findings collectively indicate that ERK signaling plays key roles in both Elk1 , CREB, and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response to TNF-alpha in pulmonary epithelial cells
Ronda et al., J Steroid Biochem Mol Biol 2007 : 1alpha,25 ( OH ) ( 2 ) D ( 3 ) and 17beta-estradiol also induced the phosphorylation of CREB and Elk-1 transcription factors in an ERK1/2 dependent manner
Cohen-Armon et al., Mol Cell 2007 (MAP Kinase Signaling System) : In cortical neurons treated with nerve growth factors and in stimulated cardiomyocytes, PARP-1 activation enhanced ERK induced Elk1-phosphorylation , core histone acetylation, and transcription of the Elk1-target gene c-fos
Lerner-Marmarosh et al., Proc Natl Acad Sci U S A 2008 (MAP Kinase Signaling System) : hBVR is a nuclear transporter of ERK ; experiments with hBVR nuclear export signal (NES) and nuclear localization signal ( NLS ) mutants demonstrated its critical role in the nuclear localization of IGF stimulated ERK for Elk1 activation
Ligeza et al., FEBS J 2008 : Silencing of CREB or Elk-1 significantly increased ERK activation observed after 5 min of morphine stimulation
Hong et al., Mol Cell Biochem 2010 : Further, ERK inhibitor inhibited significantly OPN expression, Elk1 phosphorylation, and activator protein-1 (AP-1)-DNA binding activation, but not FAK phosphorylation, in the force applied cells
Gibbs et al., J Biol Chem 2012 : Formation of ternary complex of human biliverdin reductase-protein kinase Cd-ERK2 protein is essential for ERK2 mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS)