Gene interactions and pathways from curated databases and text-mining

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HMGB1 — NOS2

Text-mined interactions from Literome

Carvajal et al., Crit Care Med 2002 (Inflammation...) : We will review the mechanisms by which HMG-I/Y proteins regulate gene transcription, give an overview of selected genes regulated by HMG-I/Y, summarize the potential roles of these genes in critical illnesses, and provide more detailed information about the role of HMG-I/Y in the regulation of nitric oxide synthase-2 during an inflammatory response, such as endotoxemia/sepsis
Ivanov et al., Blood 2007 : Loss of HMGB1 leads to a defect in the IL-6, IL-12, TNFalpha, and iNOS response to CpG-ODN