Dise et al., Am J Physiol Gastrointest Liver Physiol 2008
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Whereas EGF failed to activate Rac in colon cells from EGF receptor (EGFR) knockout mice, stable expression of wild-type EGFR restored EGF stimulated Rac activation and migration
Malliri et al., J Cell Biol 1998
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Our data establish a novel link between AP-1 activity and EGFR activation of Rac and Rho, which in turn mediate the actin cytoskeletal rearrangements required for cell motility and invasion