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CA2 — HMGCR

Text-mined interactions from Literome

Yada et al., Br J Pharmacol 1999 : The present study examined the effects of HMG-CoA reductase inhibitors on the glucose induced [Ca2+ ] i signalling and insulin secretion in rat islet beta-cells ... 6. In conclusion, lipophilic HMG-CoA reductase inhibitors can inhibit glucose induced [ Ca2+ ] i signalling and insulin secretion by blocking L-type Ca2+ channels in beta-cells, and their inhibitory potencies parallel their lipophilicities
Roitelman et al., J Biol Chem 1991 : To assess the possible role of Ca2+ in the regulated degradation of HMG-CoA reductase , we perturbed cellular Ca2+ concentration and followed the fate of HMG-CoA reductase and of HMGal, a fusion protein consisting of the membrane domain of HMG-CoA reductase and the soluble bacterial enzyme beta-galactosidase ... These results suggest that Ca2+ plays a major role in the regulated degradation of HMG-CoA reductase
Zammit et al., Biochem J 1991 : The roles of protein kinase C, Ca2+/calmodulin dependent protein kinase and AMP activated protein kinase in the phosphorylation of 3-hydroxy-3-methylglutaryl-CoA ( HMG-CoA) reductase induced by Ca2 ( + ) -mobilizing conditions in isolated hepatocytes were investigated
Beg et al., J Biol Chem 1985 : The phosphorylation and concomitant inactivation of enzymic activity of HMG-CoA reductase was absolutely dependent on Ca2+ , phosphatidylserine, and diolein
Beg et al., J Biol Chem 1987 : The elucidation of a Ca2+/calmodulin dependent HMG-CoA reductase kinase mediated modulation of HMG-CoA reductase activity involving reversible phosphorylation may provide new insights into the molecular mechanisms involved in the regulation of cholesterol biosynthesis