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Christian et al., J Biol Chem 2003
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Consistent with the idea that Rap-GTP is a negative regulator of the PI3K/Akt pathway, expressing constitutively active Rap2 ( Rap2V12 ) reduced BCR induced phosphorylation of Akt and FKHR Hinman et al., J Immunol 2007
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Previously, BCR induced phosphorylation of FOXO1 was shown to lead to a block in nuclear localization and subsequent protein degradation