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CISH — IL6
Text-mined interactions from Literome
Okabe et al., Exp Hematol 1999
:
CIS1 is
induced by interleukin-2 (IL-2), IL-3, GM-CSF, and erythropoietin (EPO), but not by
IL-6 , granulocyte colony stimulating factor ( G-CSF ), or stem cell factor
Dogusan et al., J Neuroimmunol 2000
(Leukemia) :
In tonsillar cells,
CIS expression was increased and SOCS-2 was
induced by IL-1beta,
IL-6 , PRL and GH
Lebel et al., Endocrinology 2000
(Endotoxemia) :
Selective
involvement of
interleukin-6 in the transcriptional activation of the
suppressor of cytokine signaling-3 in the brain during systemic immune challenges
Yang et al., J Hepatol 2005
(Disease Models, Animal...) :
However, several signaling pathways converge on SOCS3
: SOCS3 can be induced by other mediators in vitro, and it does not exclusively
inhibit IL-6 signaling
Kimura et al., Proc Natl Acad Sci U S A 2005
:
Suppressor of cytokine signaling-1 selectively
inhibits LPS induced
IL-6 production by regulating JAK-STAT
Xu et al., J Neuroimmunol 2006
(Inflammation) :
In LPS stimulated astrocytes,
9-cis-RA inhibited NO and TNF-alpha production but
had not effect on IL-1beta,
IL-6 and MCP-1 secretion
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3 inhibits
interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Yarwood et al., J Biol Chem 2008
:
Its ability to inhibit
interleukin (IL)-6 responses is
due to induction of
suppressor of cytokine signaling-3 ( SOCS-3 ), a negative regulator of IL-6 receptor signaling
Croker et al., Exp Hematol 2008
:
Granulocyte colony stimulating factor ( G-CSF ) and
interleukin-6 (IL-6) play key roles in regulating emergency granulopoiesis and inflammation, and are both negatively
regulated by the inducible intracellular protein
suppressor of cytokine signaling-3 ( Socs3 )
Zhang et al., J Immunol 2008
(Multiple Sclerosis) :
Our results demonstrated statin mediated increases in
suppressor of cytokine secretion (SOCS) 3 and suppressor of cytokine secretion 7, which negatively
regulate the STAT/JAK signal transduction pathway and
IL-6 and IL-23 gene expression in monocytes
Rastmanesh et al., Eur J Pharmacol 2008
(Cardiovascular Diseases...) :
IL-6 stimulation of whole blood
caused expression of different
SOCS genes in monocytes and lymphocytes
Prêle et al., J Immunol 2008
:
In addition,
SOCS1 regulated the production of
IL-6 , but not IL-10, by monocytes
Kageyama et al., J Endocrinol 2009
:
Therefore,
SOCS-3 ,
induced by a cAMP stimulant and
IL-6 , would be involved in the negative regulation of CRF gene expression in hypothalamic cells
Ma et al., J Immunol 2010
:
Moreover, we elucidated an important
role for
suppressor of cytokine signaling (SOCS) 3 in IL-17 enhancement of
IL-6 signaling in astrocytes
Kageyama et al., Vitam Horm 2010
:
Suppressor of cytokine signaling-3 , which is
induced by a cAMP stimulant and
IL-6 , is involved in the negative regulation of CRF gene expression in hypothalamic cells
Fan et al., J Cell Physiol 2011
:
AP-1, NF-IL-6, and NF-?B
cis-elements are
required for gAd induced
IL-6 transcription
Jauhonen et al., Molecular vision 2011
(MAP Kinase Signaling System) :
We have previously shown that
cis-UCA can
suppress UV-B induced
interleukin-6 and -8 secretion and cytotoxicity in human corneal epithelium (HCE) cells
Xu et al., J Interferon Cytokine Res 2012
:
In the present study, we for the first time identified that in human hepatoma cell line HepG2 the activation of FXR by the natural agonist chenodeoxycholic acid ( CDCA ) and the synthetic specific agonist GW4064 upregulated
CISH at both transcriptional and translational levels, and
inhibited interleukin (IL)6 induced STAT5 activation
Tormo et al., Cytokine 2012
:
CD4 T cell stimulation with
IL-6 induces the synthesis of
CIS , which is encoded by a gene known to be regulated by STAT5
Starr et al., Nature 1997
:
Transcription of all four
SOCS genes is increased rapidly in
response to
interleukin-6 , in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction
Ohno et al., J Med Virol 1997
:
The IL-6 stimulation was abolished by introducing a mutation either in an AP-1 related site or a C-stretch sequence in the Enh1 sequence, demonstrating that the
cis-elements are
necessary for the
IL-6 response
Suzuki et al., Oncogene 1998
(Leukemia, Myeloid, Acute) :
In M1 myeloid leukemia cells,
CIS3 was
induced by neither
interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)