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NOTCH2 — TSLP

Text-mined interactions from Literome

Dumortier et al., PloS one 2010 (Dermatitis, Atopic...) : Loss of Notch in keratinocytes induces the production of thymic stromal lymphopoietin (TSLP) , a cytokine deeply implicated in the pathogenesis of AD ... Our data demonstrate a critical role for Notch in repressing TSLP production in keratinocytes, thereby maintaining integrity of the skin and the hematopoietic system
Takai et al., Allergol Int 2012 : Skin barrier injury, increased epidermal endogenous protease activity, and less epidermal Notch signaling, all of which have been reported in atopic dermatitis, and keratinocyte-specific loss of retinoid X receptors and treatment of skin with agonists for vitamin D receptor in mice induce TSLP production, Th2 response, or atopic dermatitis-like inflammation