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BCL2 — MCL1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: BCL2 subfamily (BCL2/MCL1/BCL2L2/BCL2A1/BCL2L1) → p53/BCL2 subfamily complex (TP53-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) (modification, collaborate)
  Mihara et al., Mol Cell 2003, Marchenko et al., EMBO J 2007
  Evidence: physical interaction
• NCI Pathway Database Direct p53 effectors: PUMA/BCL2 subfamily complex (BBC3-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) → p53/BCL2 subfamily complex (TP53-BCL2_MCL1_BCL2L2_BCL2A1_BCL2L1) (modification, collaborate)
  Chipuk et al., Science 2005
  Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of CALR-BCL2-HSPA9-MCL1-BECN1 (colocalization, cosedimentation through density gradient) Germain et al., EMBO J 2011*
• IRef Intact Interaction: Complex of BAX-BCL2L1-BCL2L11-MCL1-BCL2 (association, anti bait coimmunoprecipitation) Ewings et al., EMBO J 2007*
• MIPS Negatome - no physical interaction between proteins Interaction: BCL2 — MCL1 (Absence of interaction, two hybrid) Bae et al., J Biol Chem 2000*
• IRef Ophid Interaction: BCL2 — MCL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Leu et al., Oncogene 2003 (Esophageal Neoplasms) : While Bcl-2 , Bcl-x ( L, ), and Bax were not affected, Mcl-1 was induced by IL-6 in human esophageal carcinoma cells
Hung et al., Anticancer Res 2003 (Uterine Cervical Neoplasms) : While the levels of Bcl-2 and Bcl-xL were relatively unchanged, these compounds induced a marked reduction in Mcl-1 level