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CCND1 — PIN1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wulf et al., EMBO J 2001
(Breast Neoplasms...) :
Overexpression of
Pin1 increases cellular
cyclin D1 protein and activates its promoter
Hamdane et al., J Mol Neurosci 2002
(Alzheimer Disease...) :
We also showed that in neuronal cells,
Pin1 upregulates the expression of
cyclin D1
Ryo et al., J Cell Sci 2003
(Neoplasms) :
Pin1 regulates the expression of
cyclin D1 by cooperating with Ras signaling and inhibiting the interaction of beta-catenin with the tumor suppressor APC and also directly stabilizing cyclin D1 protein
Miyashita et al., Oncol Rep 2003
(Carcinoma, Squamous Cell...) :
The differential display screen revealed that
Pin1 increases the transcription of several target genes, including
cyclin D1 and c-myc genes
Nakashima et al., J Pathol 2004
(Cell Transformation, Neoplastic...) :
Cyclin D1 is a target molecule transcriptionally activated by aberrant beta-catenin in Wnt signalling, while prolyl isomerase
Pin1 promotes
cyclin D1 overexpression directly or through accumulation of beta-catenin in cancer cells ... This study aimed to elucidate whether
Pin1 was
involved in
cyclin D1 overexpression and aberrant beta-catenin in thyroid tumourigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas ( PTCs )
Fukuchi et al., Int J Oncol 2006
(Carcinoma, Squamous Cell...) :
Here, we investigated the
role of
Pin1 in association with
cyclinD1 in esophageal SCC progression and its clinicopathological significance
Li et al., Oncol Rep 2006
(Uterine Cervical Neoplasms) :
In this study, whether
Pin1 is
involved in cervical oncogenesis by regulating
cyclin D1 was explored and the potential of Pin1 targeted gene silencing in inhibiting cellular growth and tumorigenicity in cervical cancer was investigated ... The results showed that
Pin1 directly
regulated cyclin D1 levels
Zhou et al., Oncol Rep 2006
(Carcinoma, Adenoid Cystic...) :
The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas ( SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether beta-catenin expression was aberrant in SACC and whether
Pin1 was
involved in aberrant beta-catenin and
cyclin D1 expression
Atabay et al., J Neurochem 2012
(Neurodegenerative Diseases) :
Here, we show that inhibition of
Pin1 by its selective inhibitor juglone
leads to up-regulation of
cyclinD1 , phospho-tau, and caspase 3, producing apoptosis in cultured rat hippocampal neurons