Gene interactions and pathways from curated databases and text-mining

◀ Back to CD79B

BLNK — CD79B

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Benschop et al., J Immunol 2001 : BCR induced tyrosine phosphorylation of CD79a, Lyn, B cell linker protein , and phospholipase Cgamma2 is enhanced in immature B cells and they exhibit greater capacitative calcium entry in response to Ag
Kövesdi et al., Cell Signal 2002 (Calcium Signaling) : Both BLNK and phospholipase C ( PLC ) gamma were raft associated in unstimulated pre-B cells, and this could not be enhanced by pre-BCR engagement, suggesting a ligand independent PLC gamma mediated signaling
Tsubata et al., Int Rev Immunol 2001 : BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule SLP65/BLNK
Chen et al., Blood 2008 (Calcium Signaling...) : CLL cells made to express ZAP-70, a kinase-defective ZAP-70 ( ZAP-70-KA ( 369 ) ), or a ZAP-70 unable to bind c-Cbl ( ZAP-YF ( 292 ) ) experienced greater intracellular calcium flux and had greater increases in the levels of phosphorylated p72(Syk), B-cell linker protein (BLNK) , and phospholipase C-gamma, and greater activation of the Ig accessory molecule CD79b in response to treatment with anti-mu than did mock transfected CLL cells lacking ZAP-70
Zhang et al., EMBO J 1998 : By monitoring the activation of signaling elements in pervanadate stimulated B cells expressing different levels of the BCR, we show here that phosphorylation of SLP-65 and Syk, but not of Lyn, is strictly dependent on the expression of the BCR on the cell surface