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INS — PTK2
Text-mined interactions from Literome
Corry et al., Am J Hypertens 2002
(Hyperinsulinism...) :
Insulin induced
protein tyrosine kinase activity was decreased in erythrocytes from hypertensive versus control subjects
Anderwald et al., Mol Endocrinol 2002
:
Insulin alone ( P < 0.01 ), but not leptin,
increased autophosphorylation of nonreceptor tyrosine kinases ( pp59 ( Lyn
) + pp125(Fak) )
Jou et al., Planta Med 2004
:
Moreover, genistein can activate alpha ( 1A ) -AR at a concentration ( 1 micromol/L ) lower than that ( 50 micromol/L ) needed to abolish the
insulin stimulated phosphorylation of
PTK
Strobel et al., Biochem J 2005
:
On the whole, the experimental evidence and computer simulation data favour a transport inhibition mechanism in which flavonoids and GLUT4 interact directly, rather than by a mechanism related to
protein-tyrosine kinase and
insulin signalling
inhibition
Tavaré et al., J Biol Chem 1991
:
Furthermore,
insulin stimulated exogenous
protein-tyrosine kinase activity of the mutant receptors is unaffected, as assessed following either phosphorylation of receptors in intact cells or following immunopurification of receptors and their autophosphorylation in vitro
Spicarova et al., Neuroscience 2010
(Pain...) :
The membrane permeable
protein tyrosine kinase inhibitor, lavendustin A ( 10 microM ),
prevented the
insulin induced AMPA EPSC depression
Loh et al., Diabetologia 2012
(Diabetes Mellitus, Type 2...) :
Insulin activates insulin receptor
protein tyrosine kinase and downstream phosphatidylinositol-3-kinase (PI3K)/Akt signalling in muscle to promote glucose uptake
Rosen et al., Science 1987
:
Three recent advances pertinent to the mechanism of insulin action include ( i ) the discovery that the insulin receptor is an
insulin dependent
protein tyrosine kinase , functionally related to certain growth factor receptors and oncogene encoded proteins, ( ii ) the molecular cloning of the insulin proreceptor complementary DNA, and ( iii ) evidence that the protein tyrosine kinase activity of the receptor is essential for insulin action
Chou et al., J Biol Chem 1989
(Carcinoma, Hepatocellular...) :
The receptor showed an
insulin dependent
protein tyrosine kinase activity
Cordera et al., Endocrinology 1987
:
It was observed that MA 10 inhibits insulin binding to human, but not rat, tissues while inhibiting
insulin stimulated receptor autophosphorylation and
protein tyrosine kinase activity in both human and rat tissues
Ellis et al., J Virol 1988
:
The human insulin receptor (IR) is a transmembrane glycoprotein, whose cytoplasmic domain contains an
insulin activated
protein-tyrosine kinase ( EC 2.7.1.112 )
Gherzi et al., Biochem Biophys Res Commun 1988
:
We previously demonstrated that the anti-insulin receptor monoclonal antibody MA-10 decreases
insulin stimulated receptor
protein tyrosine kinase activity `` in vitro '', without inhibiting insulin receptor binding
Hunter et al., Ciba Found Symp 1985
(Cell Transformation, Viral) :
IGF I and
insulin , whose receptors also have ligand
stimulated protein-tyrosine kinase activity, induce p42 phosphorylation in appropriate cells
Petruzzelli et al., J Biol Chem 1985
:
Acquisition of
insulin dependent
protein tyrosine kinase activity during Drosophila embryogenesis ...
Insulin dependent
protein tyrosine kinase activity has now been identified in Drosophila ... However, during the 6-12- and 12-18-h periods of embryogenesis when
insulin dependent
protein tyrosine kinase activity is expressed, another protein ( Mr = 100,000 ) becomes cross linked to 125I-insulin ... We conclude that the insulin binding and
insulin dependent
protein tyrosine kinase activities of the mammalian insulin receptor are conserved in Drosophila ... However, the
insulin dependent
protein tyrosine kinase activity of the receptor is detected only during specific times in embryogenesis
Carter et al., Biochemistry 1996
:
Phosphorylation of serine 1078 of the insulin receptor to high stoichiometry by the kinase did not affect
insulin stimulated exogenous
protein tyrosine kinase activity of the insulin receptor
Enan et al., Reprod Toxicol 1996
:
In the
presence of
insulin , TCDD did not induce any additional changes in postnuclear or nuclear
PTK
Baron et al., J Biol Chem 1998
:
Insulin induced p125(Fak) phosphorylation correlated with an increase in paxillin phosphorylation, indicating that
p125(Fak) kinase activity may be
stimulated by
insulin
Brown et al., Carcinogenesis 1998
(Neuroblastoma) :
The results showed that genistein down-regulated intrinsic PTK activity by approximately 33 % and inhibited
insulin-like growth factor (IGF) stimulated
PTK activity by 75 %
Persaud et al., J Mol Endocrinol 1999
(Second Messenger Systems) :
We have examined the effects of glucose, the major physiological insulin secretagogue, on the tyrosine phosphorylation state of islet proteins, and assessed beta cell
insulin secretory responses in the
presence of
PTK inhibitors ... The
PTK inhibitors genistein ( GS ) and tyrphostin A47 ( TA47 )
inhibited islet tyrosine kinase activities and glucose-, 4alpha ketoisocaproic acid ( KIC ) - and sulphonylurea stimulated
insulin release, without affecting glucose metabolism