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EGFR — LRIG1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Gur et al., EMBO J 2004
:
Upregulation of
LRIG1 is
followed by enhanced ubiquitylation and degradation of
EGFR
Miller et al., Cancer Res 2008
(Breast Neoplasms) :
Interestingly, we observe that
LRIG1 protein levels are suppressed in
response to
ErbB receptor activation in breast tumor cells but are unaffected by ErbB activation in immortalized nontransformed breast epithelial cells
Powell et al., Cell 2012
(Adenoma...) :
Loss of Apc in Lrig1 ( + ) cells leads to intestinal adenomas, and genetic ablation of
Lrig1 results in heightened
ErbB1-3 expression and duodenal adenomas
Wang et al., Oncol Res 2012
(Glioma) :
The mechanisms underlying the effect of the combined treatment of LRIG1 and CDDP could be that
LRIG1 blocked CDDP induced
EGFR activation and regulated the apoptosis proteins
He et al., Biochem Biophys Res Commun 2013
(Glioblastoma) :
Gambogic acid
induces EGFR degradation and Akt/mTORC1 inhibition through AMPK
dependent-LRIG1 upregulation in cultured U87 glioma cells