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AKT3 — XBP1

Text-mined interactions from Literome

Mao et al., Am J Physiol Cell Physiol 2006 : We found that the apoptotic effect of NE was associated with increased processing of ER-resident pro-caspase-12, cleavage of caspase-9 and -3, and mitochondrial release of cytochrome c. ER stress was evidenced by upregulation of ER chaperone GRP78 and transcription factor CHOP and the translocation of XBP-1 from the ER to the nucleus by NE. NE also reduced phospho-Akt ( Ser473 ), indicating suppression of the phosphatidylinositol 3-kinase ( PI3-kinase ) /Akt survival pathway
Jiang et al., Neoplasia (New York, N.Y.) 2009 (Melanoma) : Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule targeting drugs through XBP-1 mediated activation of Akt ... In addition, inhibition of XBP-1 decreased the constitutive levels of activation of Akt and blocked the activation of Akt induced by TM