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GSK3B — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hoeflich et al., Nature 2000
(Fetal Death...) :
Requirement for
glycogen synthase kinase-3beta in cell survival and
NF-kappaB activation ... The early steps leading to NF-kappaB activation ( degradation of I-kappaB and translocation of NF-kappaB to the nucleus ) were unaffected by the loss of GSK-3beta, indicating that
NF-kappaB is
regulated by
GSK-3beta at the level of the transcriptional complex
Sanchez et al., Mol Cell Biol 2003
:
In light of reports on the interplay between GSK-3beta and nuclear factor kappaB (NF-kappaB), and because of the antiapoptotic activity of NF-kappaB, we examined the
effect of
GSK-3beta overexpression on
NF-kappaB activation
Demarchi et al., J Biol Chem 2003
:
Glycogen synthase kinase-3 beta regulates
NF-kappa B1/p105 stability
Rao et al., J Biol Chem 2004
:
GSK 3beta inhibition
increased both
NFkappaB and beta-catenin activity associated with decreased IkappaB and increased beta-catenin levels
Liao et al., Mol Cancer Ther 2003
(Prostatic Neoplasms) :
Finally, Trichodion, a potent nuclear factor-kappaB (NF-kappaB) inhibitor, could not affect LiCl induced TRAIL sensitization, although
GSK-3beta inhibitors significantly
blocked TRAIL reduced
NF-kappaB activity in prostate cancer cells
Deng et al., Mol Carcinog 2004
:
In this study, we investigated whether
GSK-3beta/APC might
regulate NF-kappaB activity through beta-catenin ... We found that inhibition of
GSK-3beta suppressed
NF-kappaB activity, whereas reexpression of APC restored NF-kappaB activity in APC mutated cells
De Ketelaere et al., FEBS Lett 2004
:
Involvement of
GSK-3beta in TWEAK mediated
NF-kappaB activation
Steinbrecher et al., Mol Cell Biol 2005
:
Consistent with this result, cells from these mice have diminished nuclear factor kappaB (NF-kappaB) activity, implying a functional
role for
GSK-3beta in regulating
NF-kappaB
Vines et al., J Biol Chem 2006
:
Overexpression of
GSK-3beta did not
affect the TNF-alpha induced nuclear translocation of
NFkappaB but reduced the nuclear half-life of TNF-alpha induced NFkappaB considerably ( by as much as 9 h ) and enhanced phosphorylation ( by as much as 33 % )
Cao et al., Cell Res 2006
(Ovarian Neoplasms) :
Although glycogen synthase kinase-3 ( GSK-3 ) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt signaling pathway,
GSK-3beta may
contribute to
NF-kappaB activation in cancer cells leading to increased cancer cell proliferation and survival
Sui et al., Eur J Neurosci 2006
(AIDS Dementia Complex) :
Activation of
GSK-3beta , in turn,
results in modification of the NF-kappaB subunit
RelA at serine 468, thereby regulating the physical interaction of RelA with histone deacetylase-3 corepressor molecules
Dugo et al., Novartis Found Symp 2007
(Endotoxemia...) :
GSK-3beta inhibition
reduced the increase in
NF-kappaB p65 activity caused by interleukin (IL)1 in human e mbryonic kidney cells in vitro
Saegusa et al., J Pathol 2007
(Endometrial Neoplasms) :
In cell lines, overexpression of p65 inhibited beta-catenin/TCF4 mediated transcription, while transfection of
GSK-3beta resulted in repression of TNF-alpha induced
NF-kappaB activity
Kim et al., Brain Res 2007
:
The transcriptional activity of
NF-kappaB was significantly
increased by
GSK-3beta inhibition, which was determined by nuclear translocation of NF-kappaB
Holmes et al., Curr Med Chem 2008
(Leukemia...) :
In contrast,
GSK-3beta positively
regulates NF-kappaB , another important biochemical pathway also involved in the regulation of multiple aspects of normal and aberrant haematopoiesis ... In addition,
GSK-3beta regulates the pro-inflammatory activity of
NF-kappaB
Yang et al., Cancer Cell 2009
(Cell Transformation, Neoplastic...) :
Wu et al., in this issue of Cancer Cell, show that TNFalpha dependent
NFkappaB activation
induces COP9 signalosome mediated inhibition of
GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis
Ma et al., Toxicol Lett 2009
(Lung Diseases) :
Next, we further observed that constitutively active
GSK3beta stabilized the inhibitor of NF-kappaB ( IkappaBalpha ), inhibited p65 nuclear translocation and partially
blocked BLM induced
NF-kappaB activation
Cheng et al., Infect Immun 2009
(Inflammation) :
These results suggest that
GSK-3beta regulates heat inactivated S. aureus induced TNF-alpha and NO production in microglia mainly by activating
NF-kappaB and probably by inhibiting IL-10
Alciato et al., J Leukoc Biol 2010
:
We also observed
GSK3 beta phosphorylation and consequent
inhibition of
NF-kappaB nuclear translocation