◀ Back to RUNX2

RUNX2 — SOX9

Pathways - manually collected, often from reviews:

• WikiPathways Endochondral Ossification: SOX9 → RUNX2 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOX9 — RUNX2 (direct interaction, fluorescent resonance energy transfer) Cheng et al., J Bone Miner Res 2010*

Text-mined interactions from Literome

Lengner et al., J Biol Chem 2005 : We postulate that Runx2 is a critical link in BMP-2 mediated initiation of mesenchymal chondrogenesis that results in activation of Sox9 at least in part through the Nkx3.2 dependent repression of Runx2
Yamashita et al., Exp Cell Res 2009 : Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes
Cucchiarini et al., J Mol Med (Berl) 2013 : Remarkably, application of rAAV SOX9 delayed premature terminal differentiation and hypertrophy in the newly formed cartilage, possible due to contrasting effects of SOX9 on RUNX2 and ß-catenin osteogenic expression in this area