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JAK2 — MYLIP

Text-mined interactions from Literome

Navarro et al., Blood 2009 (Hodgkin Disease) : Regulation of JAK2 by miR-135a : prognostic impact in classic Hodgkin lymphoma ... Target analysis showed a direct regulation by miR-135a of JAK2 , a cytoplasmic tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways ... miR-135a mediated JAK2 down-regulation led to decreased mRNA and protein levels of the antiapoptotic gene Bcl-xL, suggesting a role for Bcl-xL in miR-135a/JAK2 mediated apoptosis
Ding et al., Cell Res 2010 (Stomach Neoplasms) : Forced expression of miR-375 in gastric cancer cells significantly reduced the protein level of Janus kinase 2 (JAK2) and repressed the activity of a luciferase reporter carrying the 3'-untranslated region of JAK2, which was abolished by mutation of the predicted miR-375 binding site, indicating that JAK2 may be a miR-375 target gene
Lin et al., Leukemia 2013 (Myeloproliferative Disorders) : Among the deregulated miRNAs, expression of miR-134 , -214 and -433 was not affected by changes in JAK2 activity, suggesting that additional signaling pathways are responsible for the deregulation of these miRNAs in MPN