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FOXO1 — IL1A

Text-mined interactions from Literome

Su et al., Diabetes 2009 (Diabetes Mellitus, Type 2...) : FoxO1 selectively promoted IL-1ß production in cultured macrophages ... Mutations of the FoxO1 binding site within the IL-1ß promoter abolished FoxO1 induction of IL-1ß expression
Dobierzewska et al., J Biol Chem 2012 : The IL-1ß effects on FoxO1 are counteracted, however, by the silencing or inhibition of neutral sphingomyelinase 2 (nSMase-2) using shRNAi, scyphostatin, or GW4869, as well as by the pharmacological inhibition of JNK and ERK ... In conclusion, we propose that IL-1ß regulates FoxO1 activity through a novel nSMase-2 dependent pathway